NCT04174820

Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition

Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 145 (estimated)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 6 Years – 17 Years
• Healthy volunteers: Accepted

Summary

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.

Detailed description

The physiopathology and the anatomo-functional correlates of motor, cognitive, and language functions after surgery of PF tumors are still rare and little known. The objective of this study is to analyze them via morphometric MRI analysis and functional and structural connectivity in children away from PF surgery, coupled with clinical data analysis.

Conditions

• Medulloblastoma, Childhood
• Healthy Volunteers
• Fossa Posterior Tumor
• Low-grade Glioma

Interventions

Type	Name	Description
OTHER	Functional Magnetic Resonance Imaging (fMRI)	list of the tests: Box and Blocks test, Nine Hole Peg test, walkway GAITRite, EXALang tests, NEPSY II subtests, BRIEF, FEE, WISC 5 tests

Timeline

• Start date: 2020-11-12
• Primary completion: 2022-11-01
• Completion: 2022-11-01
• First posted: 2019-11-22
• Last updated: 2020-11-19

Locations

5 sites across 1 country: France