| Not Yet Recruiting | Escalating Doses of Memantine in Down Syndrome (MEDS-123) NCT07531940 | University Hospitals Cleveland Medical Center | Phase 1 |
| Not Yet Recruiting | The Effect of Gardening Activities on the Quality of Life of Students With Mild Intellectual Disability NCT07504874 | Ordu University | N/A |
| Not Yet Recruiting | Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities NCT06997198 | University Hospitals Cleveland Medical Center | Phase 4 |
| Recruiting | Characterization of Nociception Phenotype in Individuals With Intellectual Disability NCT05473429 | National Institutes of Health Clinical Center (CC) | N/A |
| Not Yet Recruiting | Implementation of Long-read Sequencing for the Diagnosis of Rare Diseases. NCT07400913 | University Hospital, Bordeaux | — |
| Recruiting | Online Learning Module to Advance Research Related to People With Disabilities NCT07220837 | Albert Einstein College of Medicine | N/A |
| Not Yet Recruiting | A Cognitive Behavioral Therapy Approach to Addressing Anxiety in Children With ASD and Intellectual Disability NCT07245160 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Active Not Recruiting | Equine Therapy Programme on Stress, Autonomy and Balance in School-age Children With Intellectual Disabilities NCT07497035 | Universidad Pontificia Comillas | N/A |
| Recruiting | Bladder and Bowel Functions, Participation and Quality of Life in Children With Intellectual Disabilities NCT07059858 | Abant Izzet Baysal University | — |
| Recruiting | Harnessing Communication Preferences NCT07278544 | Joel E. Ringdahl | N/A |
| Recruiting | Testing an Evidence-Based Supported Employment Model in Autistic Young Adults NCT06829264 | University of California, Davis | N/A |
| Recruiting | Evaluation of the Effect of Digital-based Games on the Visual and Cognitive Performance of Young Children With NCT07476092 | Koç University | N/A |
| Not Yet Recruiting | Explore the Therapeutic Effect of Theta Burst Stimulation on Emotion Regulation in Autism With Minimally Verba NCT06974838 | Chang Gung Memorial Hospital | N/A |
| Recruiting | Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual Disabilities NCT06961591 | University of Kansas Medical Center | N/A |
| Not Yet Recruiting | Perceptual-vision Training and Intellectual Disabilities NCT06628999 | Università degli Studi dell'Insubria | N/A |
| Withdrawn | Vagus Nerve Stimulator for Autism and Other Developmental Disorders NCT06259201 | New York State Institute for Basic Research | N/A |
| Completed | Laughter Yoga's Impact on Parental Stress, Burnout, and Self-Efficacy NCT07119164 | Pamukkale University | N/A |
| Not Yet Recruiting | Search for Phenotype-modifying Genes in Patients With Intellectual Disabilities. NCT06706934 | University Hospital, Bordeaux | — |
| Recruiting | Clinical Trial of the Dual Vector Base Editor for the Treatment of the CHD3-R1025W Mutation NCT06860672 | Yongguo Yu | EARLY_Phase 1 |
| Not Yet Recruiting | Interactive Oral Health Educational Program for Children With Intellectual Disability and Their Caregivers NCT06838221 | Cairo University | — |
| Recruiting | Physical Activity and Community EmPOWERment Project NCT06740162 | University of North Carolina, Chapel Hill | N/A |
| Withdrawn | Valbenazine Treatment of Tardive Dyskinesia in Adults With Intellectual/Developmental Disabilities NCT06107829 | Stephen Ruedrich | Phase 4 |
| Completed | Therapeutic Play in Children With Mild Intellectual Disability NCT06735482 | Beni-Suef University | N/A |
| Completed | Developing a Falls Management Tool for Adults With ID-POC NCT06392113 | Nottingham University Hospitals NHS Trust | — |
| Recruiting | Neuropsychiatric Research Databases for People With Intellectual Disabilities and Epilepsy (REFINE) NCT06780501 | University of Plymouth | — |
| Recruiting | Effects of Adaptive Physical Activity on Health-related Fitness of Students With Intellectual Disabilitiesdisa NCT06444659 | Hunan Normal University | N/A |
| Completed | Impact of Competency-Based Training and Technical Assistance Employment Outcomes of Individuals With ID/DD NCT06586827 | Virginia Commonwealth University | Phase 1 |
| Not Yet Recruiting | Sleep in Children With Autism and Intellectual Disability NCT06403969 | Värmland County Council, Sweden | N/A |
| Recruiting | Development and Validation of the Observatory Battery of Common Eye Disorders for Adults With Intellectual Dis NCT06737627 | National Taiwan University Hospital | — |
| Unknown | Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Intellectual Disabilities NCT05473377 | Kaohsiung Medical University Chung-Ho Memorial Hospital | — |
| Recruiting | Future Planning and Well-Being for Individuals With Intellectual Disabilities and Family Caregivers NCT06065527 | Northwell Health | N/A |
| Unknown | Anti-psychotic Drug Prescribing Patterns Within Specialist Adult ID Services in England and Wales NCT06238089 | University of Plymouth | — |
| Recruiting | MEHMO Natural History and Biomarkers NCT06019182 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Unknown | Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial. NCT06063239 | G. d'Annunzio University | N/A |
| Recruiting | Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT NCT06086951 | Chinese University of Hong Kong | N/A |
| Completed | Therapy-Based Games' Effects on Motor and Cognitive Skills in Intellectual Disabilities NCT06097819 | Istanbul Medipol University Hospital | N/A |
| Completed | Use of MRI and cTBS for Catatonia in Autism NCT06016764 | Vanderbilt University Medical Center | Phase 1 |
| Unknown | Early Life Anemia and Children's Risk of Neurodevelopmental Disorders: National and Regional Register-based St NCT06199362 | Karolinska Institutet | — |
| Active Not Recruiting | Improving the Health of Parents and Their Adolescent and Transition-age Youth With Intellectual and Developmen NCT05986305 | University of North Carolina, Chapel Hill | N/A |
| Completed | Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability NCT05822596 | The University of Hong Kong | N/A |
| Recruiting | FAB Programme for Parents of Children With NDD NCT05872737 | Chinese University of Hong Kong | N/A |
| Recruiting | Effects of Physical Activity on Prescription (PAP) as a Health-enhancing Intervention in People With Disabilit NCT05867940 | Region Skane | N/A |
| Completed | Written Language Intervention for Adults With Intellectual and Developmental Disabilities NCT05851937 | Baylor University | N/A |
| Completed | Expanding Interventions for Automatically Maintained SIB NCT06739616 | University of Georgia | N/A |
| Unknown | Feasibility and Usability of a Virtual Reality System NCT06291532 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Recruiting | Mental Health Crises in Youth With IDDs NCT05471232 | Rady Pediatric Genomics & Systems Medicine Institute | — |
| Recruiting | Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability NCT05744479 | Centre for Addiction and Mental Health | Phase 4 |
| Recruiting | Heart Rate Informed Changes in Care for Non-Communicating Patients NCT05738278 | University of Oslo | N/A |
| Enrolling By Invitation | Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities NCT05301361 | University of California, Davis | Phase 1 |
| Unknown | Functional Tests to Resolve Unsolved Rare Diseases. Rares. NCT05696912 | University Hospital, Bordeaux | N/A |
| Completed | The Effect of Transition to Adulthood Education Program on Family Quality of Life and Perceived Stress Level NCT05587647 | Koç University | N/A |
| Recruiting | Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numer NCT05290051 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Recruiting | Evaluation of a Home-based Parenting Support Program: Parenting Young Children NCT05935722 | Örebro University, Sweden | N/A |
| Recruiting | Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin NCT05767203 | Institut Jerome Lejeune | N/A |
| Terminated | Improving Treatment for Children With Intellectual and Developmental Disabilities and Problem Behavior in Scho NCT05445596 | Western Kentucky University | N/A |
| Recruiting | Rett Syndrome Registry NCT05432349 | International Rett Syndrome Foundation | — |
| Recruiting | Enhancing Mother-Child Ties and Psychosocial Wellness Through Arts Among Children With Intellectual Disability NCT05214859 | The University of Hong Kong | N/A |
| Recruiting | Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth NCT05743439 | Oregon Health and Science University | N/A |
| Completed | Methylation Pattern and Pain Sensation in Children With Intellectual Disability NCT06317506 | IRCCS Burlo Garofolo | — |
| Completed | Fit Families Multisite NCT05451459 | University of Wisconsin, Madison | N/A |
| Completed | Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities NCT05273320 | Hsiang-Yuan Lin | Phase 1 |
| Unknown | Music-visual Guided Physical Activity Promotion for Adults With Intellectual Disabilities NCT04938999 | Chinese University of Hong Kong | N/A |
| Completed | Move it, Move ID! Promotion of Physical Activity in Adolescents With Intellectual Disability NCT05149443 | University Ghent | N/A |
| Active Not Recruiting | Facing Your Fears: Adolescents With ASD and Intellectual Disability NCT05131425 | University of Colorado, Denver | N/A |
| Completed | Motor and Cognitive Dual-task Gait Training Effect Functional Outcome in Intellectual Disability NCT05334498 | Riphah International University | N/A |
| Recruiting | Register for Patients With Thyroid Hormone Resistance. NCT06566066 | Charite University, Berlin, Germany | — |
| Completed | Telehealth Mindfulness-Based Music and Songwriting for Parents of Children With Intellectual/Developmental Dis NCT04962659 | Vanderbilt University Medical Center | N/A |
| Active Not Recruiting | We Walk Plus Study for Older Adults With Intellectual Disabilities NCT04573530 | University of Illinois at Chicago | N/A |
| Completed | Safer Online Lives: Use of the Internet & Social Media by People With Intellectual Disabilities NCT04919213 | University of Kent | — |
| Completed | Evaluation of the Effectiveness of Cannabidiol in Treating Severe Behavioural Problems in Children and Adolesc NCT04821856 | Murdoch Childrens Research Institute | Phase 2 |
| Completed | Physical Activity, mHealth and Intellectual Disability - a Pilot Study NCT04929106 | University Hospital of North Norway | N/A |
| Completed | Pilot Project of Forest Bathing for Promoting Health NCT05472571 | Clinica Universidad de Navarra, Universidad de Navarra | N/A |
| Completed | Analysis of the Physical Fitness Development Trajectory of Children and Adolescents With Severe Intellectual D NCT07291115 | Xili Wen | — |
| Unknown | Determining the Effectiveness of Sexual Health and Development Education for Children With Intellectual Disabi NCT04635969 | Aylin KURT | N/A |
| Unknown | Internet-delivered ACT (I-Navigator ACT) for Parents of Children With Disabilities NCT05940168 | Karolinska Institutet | N/A |
| Completed | Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader NCT05657860 | Maimonides Medical Center | Phase 4 |
| Unknown | Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal NCT05295277 | Bionano Genomics | — |
| Unknown | Study to Compare Clozapine vs Treatment as Usual in People With Intellectual Disability & Treatment-resistant NCT04529226 | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Phase 2 |
| Completed | The Quality of Life, Perceived Stress and Coping Ways of Caregivers of Mentally Handicapped Individuals NCT04790461 | Kafkas University | N/A |
| Completed | Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-1 NCT04565509 | Washington University School of Medicine | N/A |
| Completed | Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental D NCT04726371 | Massachusetts General Hospital | N/A |
| Completed | Effectiveness of Music Therapy in Social Skill Intervention for Children With ASD/ID NCT04557488 | Education University of Hong Kong | N/A |
| Completed | Dietary Intervention and Adults With Intellectual Disabilities NCT04436692 | University of Oslo | N/A |
| Unknown | A Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Children NCT05451238 | Kaohsiung Medical University Chung-Ho Memorial Hospital | — |
| Completed | Compassionate Imagery for People With An Intellectual Disability NCT05339191 | NHS Lanarkshire | N/A |
| Recruiting | A Computer-based Cognitive Remediation Program for Adults With Intellectual Disability NCT04025398 | Hôpital le Vinatier | N/A |
| Withdrawn | Study of Mindfulness Course for Parents of Adults With Intellectual Disabilities NCT04294082 | University of Edinburgh | — |
| Completed | Neonatal Seizure Registry - Developmental Functional EValuation NCT04337697 | University of California, San Francisco | — |
| Completed | Genome Sequencing Strategies for Genetics Diagnosis of Patients With Intellectual Disability NCT04154891 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Effects of Vocational Rehabilitation Group Intervention on Motivation and Occupational Self-Awareness in Indiv NCT04728074 | Hacettepe University | N/A |
| Recruiting | Sensors for Communication for Persons Who Cannot Communicate Unequivocally NCT04199299 | University of Oslo | — |
| Completed | New Skills - No Scores Research Study NCT04254666 | University of Massachusetts, Worcester | N/A |
| Completed | Research Engagement With People With Intellectual and Developmental Disabilities NCT04182347 | University of Wisconsin, Madison | N/A |
| Terminated | Physical Activity With Tailored E-health Support for Individuals With Intellectual Disability NCT04079439 | University Hospital of North Norway | N/A |
| Completed | Self-Monitoring Shopping Intervention NCT04020302 | Columbia University | N/A |
| Completed | Process and Outcomes of Horticultural Therapy for People With Disabilities NCT04917666 | The Hong Kong Polytechnic University | N/A |
| Completed | Expert Guiding Technology to Help Individuals With Developmental Challenges Build Life and Vocational Skills NCT04518358 | John T. Nosek | N/A |
| Unknown | Physical Activity, Sports and Health in Adults With Intellectual Disabilities NCT05336487 | University of Copenhagen | N/A |
| Recruiting | Evaluating the Treatment in the MZEB Aachen NCT04781452 | RWTH Aachen University | — |
| Completed | Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Co NCT05193890 | Central Hospital, Nancy, France | — |
| Completed | A Trial of Metformin in Individuals With Fragile X Syndrome (Met) NCT03862950 | University of Alberta | Phase 2 |
| Completed | The Effects of Therapeutic Recreation Activities on Aberrant Behaviours of Individuals With Intellectual Disab NCT04546464 | Selcuk University | N/A |
| Completed | Learning Through Play (LTP) in My Own Way Plus CBT NCT03683706 | Pakistan Institute of Living and Learning | N/A |
| Completed | The Effects of Therapeutic Recreation Activities on Emotional Adjustment of Individuals With Intellectual Disa NCT04102683 | Selcuk University | N/A |
| Completed | Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities NCT03684512 | University of Kansas | N/A |
| Completed | North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 NCT03548779 | University of North Carolina, Chapel Hill | N/A |
| Completed | Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test NCT03722212 | METAFORA biosystems | N/A |
| Unknown | Second Molecular Event Identification by Exome Sequencing for Intellectually Disabled Patients Carrying 16p13. NCT03644797 | Hospices Civils de Lyon | — |
| Completed | Effects of a PA Intervention for Fatness and Fitness in Adolescents With Intellectual Disability NCT04554355 | Hong Kong Baptist University | N/A |
| Completed | Intensive Support Teams Study NCT03586375 | University College, London | — |
| Withdrawn | Biomarker for Creatine Deficiency Syndromes (BioCDS) NCT02934854 | CENTOGENE GmbH Rostock | — |
| Recruiting | Longitudinal Study of Neurogenetic Disorders NCT03492060 | Columbia University | — |
| Completed | Mapping the Phenotype in Adults With Phelan-McDermid Syndrome NCT03426059 | Boston Children's Hospital | — |
| Unknown | Supervised Brushing Programme for Intellectual Disabled Students NCT03234231 | MD Equation | N/A |
| Completed | A Trial of Metformin in Individuals With Fragile X Syndrome NCT03479476 | University of California, Davis | Phase 2 / Phase 3 |
| Completed | A Pilot Trial of Mindfulness Based Intervention Program for People With Intellectual Disabilities in a Low Inc NCT03501914 | Pakistan Institute of Living and Learning | N/A |
| Unknown | Whole Genome Sequencing in the Detection of Rare Undiagnosed Genetic Diseases in Children in China NCT03424772 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Completed | Effects of Guided Exercise on Functional Performance and Independence in Adults With Intellectual Disability NCT04616638 | University of Delaware | N/A |
| Completed | Reducing Aggression Among People With an Intellectual Disability NCT03212092 | Leiden University Medical Center | N/A |
| Completed | Motor Impairments in Children With Autism Spectrum Disorder: a Multimodal Approach NCT04769011 | IRCCS Eugenio Medea | N/A |
| Unknown | Prevention Among Young People With Intellectual Disability NCT03348124 | Uppsala University | N/A |
| Completed | Clinical Utility of Pediatric Whole Exome Sequencing NCT03525431 | University of California, San Francisco | N/A |
| Completed | Effect of Sensory Adapted Dental Environment on Dental Anxiety of Children With Intellectual and Developmental NCT03218462 | Virginia Commonwealth University | N/A |
| Completed | Psychotropic Medication and Psychotherapeutic Treatment of Adults With Intellectual Disabilities NCT03558815 | Technische Universität Dresden | — |
| Completed | Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome NCT03135236 | Wake Forest University Health Sciences | N/A |
| Completed | Postural Control, Grip Strength and Body Posture in Children With Intellectual Disability and Dyslexia NCT04250701 | Ahmet Emir | — |
| Enrolling By Invitation | Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disab NCT02914951 | Yale University | N/A |
| Unknown | Various Type of Genetic Events in Patients With Intellectual Disability NCT02881333 | University Hospital, Strasbourg, France | — |
| Completed | Effectiveness of Active Video Games in Children With Intellectual Disabilities NCT04277130 | Hong Kong Baptist University | N/A |
| Completed | POWERSforID: A Telehealth Weight Management System for Adults With Intellectual Disability NCT03139760 | University of Alabama at Birmingham | N/A |
| Completed | Dialectical Behaviour Group Therapy for Adults With Intellectual Disabilities NCT02919826 | Dr. Jessica Jones | N/A |
| Recruiting | Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Ep NCT05751525 | Royal Devon and Exeter NHS Foundation Trust | — |
| Completed | Oral Health Promotion Among Preschool Children With Special Needs NCT03522337 | The University of Hong Kong | N/A |
| Completed | Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Popul NCT02486081 | Chang Gung Memorial Hospital | — |
| Unknown | Augmentative and Alternative Communication in Games With Virtual Reality in Intellectual Disabilities NCT03033797 | Faculdade de Medicina do ABC | N/A |
| Unknown | FCT With Young Children With ID in the UK: A Feasibility Project V.1 NCT02721394 | University of Kent | N/A |
| Completed | The Feldenkrais Method for People With Intellectual Disability NCT03203226 | University of the Basque Country (UPV/EHU) | N/A |
| Completed | Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients NCT02504502 | Geisinger Clinic | N/A |
| Completed | Targeted Next Generation Sequencing and Intellectual Disability NCT02889068 | Central Hospital, Nancy, France | — |
| Active Not Recruiting | Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome NCT02461420 | Boston Children's Hospital | — |
| Completed | TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders NCT02836405 | Boston Children's Hospital | — |
| Active Not Recruiting | Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TS NCT02461459 | Boston Children's Hospital | — |
| Completed | Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome NCT02616796 | Stanford University | Phase 1 / Phase 2 |
| Completed | Apparently Balanced Chromosomal Translocation/ Next-generation Sequencing/ Intellectual Disability NCT02451761 | Hospices Civils de Lyon | — |
| Completed | Weight Management for Adolescents With IDD NCT02561754 | University of Kansas Medical Center | N/A |
| Completed | Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chroni NCT02270736 | Merz Pharmaceuticals GmbH | Phase 3 |
| Completed | Motor Skill Proficiency After Equine-assisted Activities and Brain-building Tasks NCT04158960 | Texas Woman's University | N/A |
| Completed | Down Syndrome Memantine Follow-up Study NCT02304302 | University Hospitals Cleveland Medical Center | Phase 2 |
| Completed | Transcranial Magnetic Stimulation Studies in Autism Spectrum Disorders NCT02591446 | Rhode Island Hospital | — |
| Completed | Occupational Self-Analysis Programme NCT03989388 | University of Malaga | N/A |
| Completed | Psychomotor Therapy Effects in Adaptive Behavior and Motor Proficiency in Intellectual Disability NCT02746614 | Faculdade de Motricidade Humana | N/A |
| Completed | Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood NCT02225041 | University of Pennsylvania | — |
| Completed | Establishing the Clinical Utility of First StepDx PLUS and NextStepDx PLUS Study NCT02414438 | Qure Healthcare, LLC | N/A |
| Completed | Support Staff-client Interactions With Augmentative and Alternative Communication NCT02099773 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Improving Adherence Healthy Lifestyle With a Smartphone Application Based on Adults With Intellectual Disabili NCT01915381 | University of Malaga | N/A |
| Completed | Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study NCT02513277 | University of Leicester | — |
| Completed | Research and Characterization of New Genes Involved in Intellectual Disability NCT01867554 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Completed | Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications) NCT02714868 | Boston University Charles River Campus | N/A |
| Completed | Mental Health Care Provision for Adults With Intellectual Disability and a Mental Disorder NCT01695395 | Technische Universität Dresden | — |