NCT06016764

Use of MRI and cTBS for Catatonia in Autism

Use of Magnetic Resonance Imaging and Continuous Theta Burst Stimulation for Catatonia in Autism

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 15 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Despite the significant morbidity and mortality associated with catatonia in autism, no diagnostic research has attempted to identify biomarkers for catatonia. This application will use a participant's own individual brain magnetic resonance image to target the primary motor strip with transcranial magnetic stimulation; to determine if hyper-excitability of the brain directly correlates with symptoms of catatonia and social-emotional impairment in autism. Completion of this project would result in the first study to associate hyper-excitability of the brain with catatonia and core features of autism; findings which are likely to have a significant impact on the health and well-being of autistic individuals.

Conditions

• Autism Spectrum Disorder
• Catatonia
• Intellectual Disability

Interventions

Type	Name	Description
DEVICE	Continuous Theta Burst in Transcranial Magnetic Stimulation	This application will use a participant's own individual brain magnetic resonance image to target the primary motor strip with transcranial magnetic stimulation; to determine if hyper-excitability of the brain directly correlates with symptoms of catatonia, intellectual disability, and social-emotional impairment in autism

Timeline

• Start date: 2023-08-23
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2023-08-30
• Last updated: 2025-12-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study