| Not Yet Recruiting | Functional Milk Supplementation to Reduce In-Stent Restenosis in STEMI Patients (SMASOEA Trial) NCT07176104 | Raffaele Marfella | N/A |
| Not Yet Recruiting | Target Vessel Failure After Laser Assisted Percutaneous Angioplasty Versus Balloon-based Treatment for Drug El NCT07382154 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Recruiting | Intravascular Imaging-Guided Versus Angiography- Guided PCI in Patients With DES-ISR NCT07297641 | Nanjing First Hospital, Nanjing Medical University | — |
| Active Not Recruiting | VAP-Measured Lipid Subfractions and In-Stent Restenosis After PCI NCT07533656 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Active Not Recruiting | A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects Wit NCT06492174 | Boston Scientific Corporation | Phase 3 |
| Recruiting | Pilot Study of the α Prototype NIMBLE System: Feasibility, Safety, and Initial Performance in Non-Invasive Det NCT06968858 | Nimble Diagnostics S.L. | Phase 1 / Phase 2 |
| Active Not Recruiting | Pilot Study of the Coronary Spur Stent for In-stent Restenosis (DEEPER CORONARY) NCT06117150 | ReFlow Medical, Inc. | Phase 1 |
| Recruiting | MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions NCT05908331 | Concept Medical Inc. | N/A |
| Unknown | Role of Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention NCT06148441 | Assiut University | — |
| Recruiting | Anti-inflammatory Therapy for Recurrent In-stent Restenosis NCT06090890 | Fu Wai Hospital, Beijing, China | Phase 4 |
| Recruiting | Safety and Efficacy of Paclitaxel Coated PTCA Balloon Catheter With a Shellac Plus Vitamin E Excipient (GENOSS NCT06104007 | Seoul National University Hospital | — |
| Withdrawn | Resveratrol Excipient Paclitaxel Coated Balloon for Coronary Treatment NCT05093244 | B. Braun Medical Inc. | N/A |
| Unknown | Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO) NCT05623995 | Lin Zhao | Phase 4 |
| Unknown | CT-FFR-guided Strategy for In-stent Restenosis NCT05611190 | Yan'an Affiliated Hospital of Kunming Medical University | N/A |
| Completed | Compare the Effectiveness and Safety of Two Different Kinds of Cutting Balloon in Coronary Artery Disease NCT05509296 | Sino Medical Sciences Technology Inc. | N/A |
| Active Not Recruiting | Safety and Efficacy of Paclitax Coated Balloon in Patients With Coronary In-stent Restenosis (ISR) NCT05656118 | Yonsei University | — |
| Unknown | Lesion Preparation in Femoropopliteal Artery Occlusion Disease NCT05473884 | Shanghai Pudong Hospital | — |
| Completed | A Study to EXhibit Percutaneous Coronary Artery Dilatation With Non-Slip Element Balloon NCT04985773 | Infraredx | N/A |
| Completed | CVT-ISR First in Human Trial for Coronary In-Stent Restenosis NCT05731700 | Abbott Medical Devices | N/A |
| Active Not Recruiting | A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects Wit NCT04647253 | Boston Scientific Corporation | Phase 3 |
| Completed | Sirolimus-Coated Balloon Versus Paclitaxel-Coated Balloon for the Treatment of Coronary In-Stent Restenosis NCT04240444 | B. Braun Medical International Trading Company Ltd. | N/A |
| Unknown | A Comparison Between FFR Guided and CAG Guided Treatment Using DEB in ISR of DES NCT04518826 | Shanghai Zhongshan Hospital | — |
| Unknown | Biolimus A9™ (BA9™) Drug Coated Balloon (DCB) Study NCT04079192 | Biosensors Europe SA | N/A |
| Active Not Recruiting | Coronary Laser in Undilatable or Uncrossable Lesions NCT07206082 | Hospital Universitario La Paz | — |
| Completed | In-stent Restenosis and Pericoronary Fat Attenuation Index NCT05512832 | RenJi Hospital | — |
| Completed | Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT NCT04268875 | University Hospital, Clermont-Ferrand | N/A |
| Completed | IVL for Stent Underexpantsion NCT05112250 | Medical University of Silesia | — |
| Completed | DEB vs Thin-DES in DES-ISR: Long Term Outcomes (DEB Dragon Registry) NCT04415216 | Medical University of Silesia | — |
| Unknown | Optical Coherence Tomography Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis NCT03809754 | Chinese PLA General Hospital | N/A |
| Unknown | The Effect of Sleep Quality on Coronary Artery Disease and In Stent Restenosis NCT03874481 | China National Center for Cardiovascular Diseases | — |
| Unknown | Metal Allergy In-Stent Restenosis Study NCT03588962 | Silesian Centre for Heart Diseases | N/A |
| Unknown | LDD in Treatment of Femoropopliteal ISR NCT03521843 | RenJi Hospital | N/A |
| Completed | The PREVAIL Study NCT03260517 | Medtronic Vascular | N/A |
| Unknown | Comparing the Safety and Efficacy of Paclitaxel Controlled Release Balloon Catheter in the Treatment of In-ste NCT02891018 | Shandong Branden Med.Device Co.,Ltd | Phase 3 |
| Unknown | Absorb Bioresorbable Scaffold vs. Drug Coated Balloon for Treatment Of In-Stent-Restenosis NCT03529006 | Luzerner Kantonsspital | N/A |
| Unknown | Identification of Neoatherosclerosis in ISR Patients Based on Artifical Intelligence NCT04220437 | Chinese PLA General Hospital | — |
| Unknown | Restenosis Treatment With Rapamycin Eluting Stent or Paclitaxel Eluting Balloon Catheter (RESTENOZA) NCT01255956 | Medical University of Warsaw | Phase 3 |
| Unknown | DARE-trial: A Trial Studying the Effect of the SeQuent Please Drug-eluting Balloon Compared to the Xience Prim NCT01127958 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | RIBS V (Restenosis Intra-stent of Bare Metal Stents: Paclitaxel-eluting Balloon vs Everolimus-eluting Stent) NCT01239953 | Fundación Médica para la Investigación y Desarrollo en el Area Cardiovascular | Phase 4 |
| Unknown | RIBS IV (Restenosis Intra-stent of Drug-eluting Stents: Paclitaxel-eluting Balloon vs Everolimus-eluting Stent NCT01239940 | Fundación Médica para la Investigación y Desarrollo en el Area Cardiovascular | Phase 4 |
| Unknown | Treatment of Drug-eluting Stent (DES) In-Stent Restenosis With SeQuent® Please Paclitaxel Eluting Percutaneous NCT00998439 | Klinikum Coburg | Phase 2 |
| Completed | PERVIDEO I Registry, The Lutonix Paclitaxel-Coated Balloon Catheter for the Treatment of Coronary In-Stent Res NCT00916279 | C. R. Bard | Phase 1 / Phase 2 |
| Completed | Diffuse Type In-Stent Restenosis After Drug-Eluting Stent NCT00485030 | Seung-Jung Park | Phase 4 |
| Completed | Focal In-stent Restenosis After Drug-Eluting Stent NCT00485004 | Seung-Jung Park | Phase 4 |
| Completed | P E P C A D II, The Paclitaxel-Eluting PTCA-Balloon Catheter in Coronary Artery Disease to Treat In-Stent Rest NCT00393315 | University Hospital, Saarland | Phase 2 |
| Completed | Genomics of In-Stent Restenosis NCT00341562 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Sirolimus-Eluting Stent vs. Intravascular Brachytherapy in In-Stent Restenotic Coronary Artery Lesions(SISR) NCT00231257 | Cordis US Corp. | Phase 3 |