| Not Yet Recruiting | Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to NCT07429786 | Cosmetique Active International | N/A |
| Not Yet Recruiting | Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improvi NCT07324759 | NovoBliss Research Pvt Ltd | N/A |
| Enrolling By Invitation | An 18-week Study to Evaluate a Test Product With a Marketed Prescription Product NCT07136766 | Good Molecules, LLC | Phase 3 |
| Active Not Recruiting | Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent NCT07162623 | NovoBliss Research Pvt Ltd | N/A |
| Recruiting | The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmen NCT07067879 | Chulalongkorn University | N/A |
| Completed | A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmen NCT07468175 | Revision Skincare | N/A |
| Completed | Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen NCT07501000 | Revision Skincare | N/A |
| Recruiting | Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origi NCT06253468 | Cosmetique Active International | N/A |
| Completed | Efficacy of Cosmetic Products in Preventing Pigmentation Induced by High Energy Visible Light (HEVL) [400-450n NCT07537595 | Cosmetique Active International | — |
| Recruiting | Pilot Study of LED for PIE and PIH NCT06349447 | Yanjun Dan | N/A |
| Recruiting | Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 O NCT06268496 | Cosmetique Active International | N/A |
| Unknown | Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origi NCT06320314 | Cosmetique Active International | N/A |
| Completed | The Efficacy Tretinoin Cream in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigrica NCT06213987 | Srinakharinwirot University | Phase 3 |
| Unknown | Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 O NCT06234527 | Cosmetique Active International | N/A |
| Active Not Recruiting | Effectiveness of Omega-3 Poly Unsaturated Fatty Acids on The Treatment of Gingival Hyperpigmentation NCT07067515 | Suez Canal University | Phase 1 / Phase 2 |
| Completed | Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 O NCT06253455 | Cosmetique Active International | N/A |
| Completed | The Effects of Cetyl Tranexamate Mesylate on the Appearance of Acne-Related Hyperpigmentation NCT06080035 | Integrative Skin Science and Research | N/A |
| Recruiting | Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin o NCT05362929 | Albert Einstein College of Medicine | N/A |
| Completed | Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI NCT05493280 | University of Texas Southwestern Medical Center | N/A |
| Completed | Efficacy of Ceramic Soft Tissue Trimming Bur Versus Conventional Scalpel Technique in Ginigival Depigmentation NCT06031116 | Ain Shams University | N/A |
| Completed | A Safety and Effectiveness Study of CELLBOOSTER® Lift (Stabilized Booster Complex Using CHAC Technology) NCT06000839 | Suisselle | N/A |
| Completed | Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmen NCT05511948 | DermBiont, Inc. | Phase 2 |
| Completed | Brightening Cream and Lasers in Post-sclerotherapy Hyperpigmentation NCT05165524 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Fat Grafting an Ideal Filler For Contour Deformities With Hyperpigmentation On Face NCT06103461 | King Edward Medical University | N/A |
| Completed | Annurca Apple Peel Oleolite for the Treatment of Skin Hyperpigmentation NCT07040345 | Ritamaria Di Lorenzo | N/A |
| Completed | A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment f NCT05423873 | Revision Skincare | N/A |
| Completed | A Study on Pigmentation Disorders in Children NCT06189768 | Nepal Health Research Council | — |
| Unknown | Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma NCT04765930 | Cairo University | N/A |
| Completed | Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging NCT04586816 | Integrative Skin Science and Research | N/A |
| Completed | Characterization of Dyschromic Hypertrophic Scar NCT04619589 | Medstar Health Research Institute | — |
| Completed | Effectiveness of Epidermal Growth Factor-containing Ointment on the Solar Lentigines NCT04704245 | Hallym University Kangnam Sacred Heart Hospital | N/A |
| Completed | Evaluation of an Herbal-Based De-Pigmenting System NCT02138539 | Sadick Research Group | Phase 4 |
| Completed | Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy NCT03457246 | Pierre Fabre Dermo Cosmetique | N/A |
| Completed | Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation NCT01542138 | Universidad Autonoma de San Luis Potosí | Phase 4 |
| Completed | Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots NCT01149876 | Massachusetts General Hospital | Phase 4 |
| Completed | Identification of Gene Biomarkers in Aging Skin NCT00884936 | Interleukin Genetics, Inc. | — |
| Terminated | In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy NCT00771355 | Massachusetts General Hospital | — |
| Completed | Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment NCT00287001 | Mahidol University | N/A |