Trials / Completed
CompletedNCT04704245
Effectiveness of Epidermal Growth Factor-containing Ointment on the Solar Lentigines
A Randomized Controlled Trial on the Effectiveness of Epidermal Growth Factor-containing Ointment on the Treatment of Solar Lentigines as Adjuvant Therapy
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years
- Healthy volunteers
- Accepted
Summary
Subjects were randomly assigned to groups for treatment with either an EGF-containing ointment (the study group) or the vehicle alone (petrolatum; the control group). The EGF ointment included recombinant human EGF (1 μg/g). Random numbers used for assignment to groups were provided by the randomization function of SAS. The subjects received one session of laser treatment with a Q-switched (QS) 532-nm Nd:yttrium aluminum garnet (YAG) laser of their solar lentigines after enrollment. . The end point of laser treatment for lentigines was immediate whitening. The subjects then applied the EGF ointment or vehicle twice daily (morning and evening) to the lesion for 4 weeks after laser treatment.
Conditions
- Epidermal Growth Factor
- Nd-yttrium Aluminum Garnet Laser
- Hyperpigmentation
- Post Inflammatory Hyperpigmentation
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | epidermal growth factor (EGF)-containing ointment | The subjects applied the epidermal growth factor (EGF) ointment twice daily (morning and evening) to the lesion for 4 weeks after laser treatment. |
| DRUG | Vehicle ointment | To compare the effect of epidermal growth factor (EGF) ointment, the control subjects applied the vehicle ointment twice daily (morning and evening) to the lesion for 4 weeks after laser treatment. |
| PROCEDURE | Q-swithced (QS) 532-nm Nd:yttrium aluminum garnet (YAG) laser | The subjects received one session of laser treatment with a Q-swithced (QS) 532-nm Nd:yttrium aluminum garnet (YAG) laser of their solar lentigines after enrollment. The procedure parameters were as follows: 5-10-ns pulse duration, 3.5-mm spot size, 0.9-1.1-J/cm2 fluence, and 2-Hz frequency. The end point of laser treatment for lentigines was immediate whitening. |
Timeline
- Start date
- 2017-07-20
- Primary completion
- 2018-09-20
- Completion
- 2018-12-26
- First posted
- 2021-01-11
- Last updated
- 2021-01-11
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT04704245. Inclusion in this directory is not an endorsement.