| Recruiting | Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease NCT07480720 | Elazıg Fethi Sekin Sehir Hastanesi | — |
| Not Yet Recruiting | Statin and Vitamin D Treatment in Patients With Thyroid Eye Disease NCT07400757 | Taipei Veterans General Hospital, Taiwan | N/A |
| Enrolling By Invitation | Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients With Graves Disease NCT07332988 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Enrolling By Invitation | Multi-center Prospective Clinical Study on Glucocorticoid Pulse Therapy for Graves' Ophthalmopathy (GO) NCT06693856 | Zou Junjie | N/A |
| Recruiting | Modified Orbital Decompression in the Treatment of Moderate-to-severe Grave's Ophthalmopathy NCT06588764 | Sun Yat-sen University | N/A |
| Not Yet Recruiting | A Randomized Clinical Trial of Intravenous Methylprednisolone With 2 Protocols in Patients With Graves Orbitop NCT06510114 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 4 |
| Not Yet Recruiting | Study on Efficacy of Add on Selenium in Mild-to-moderate Graves Ophthalmopathy NCT06413043 | All India Institute of Medical Sciences, Bhubaneswar | N/A |
| Completed | A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease NCT06226545 | Lassen Therapeutics Inc. | Phase 2 |
| Recruiting | Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TE NCT06112340 | Sling Therapeutics, Inc. | Phase 2 / Phase 3 |
| Unknown | Sirolimus for Graves' Orbitopathy (GO) NCT04598815 | University of Pisa | Phase 2 |
| Unknown | Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbito NCT05532072 | First Affiliated Hospital Xi'an Jiaotong University | EARLY_Phase 1 |
| Active Not Recruiting | A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED) NCT05276063 | Sling Therapeutics, Inc. | Phase 2 / Phase 3 |
| Recruiting | Hydroxychloroquine in Mild Graves' Orbitopathy NCT05126147 | National Taiwan University Hospital | Phase 4 |
| Unknown | Supramaximal Rectus Recession for Strabismus in Grave's Ophthalmopathy NCT04927468 | Sun Yat-sen University | N/A |
| Recruiting | The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction NCT06275373 | Walter Reed National Military Medical Center | — |
| Completed | Sirolimus in Graves' Orbitopathy NCT05345119 | University of Pisa | — |
| Completed | Genetics and Epigenetics of Graves' Orbitopathy NCT04488406 | University of Pisa | — |
| Unknown | Tocilizumab in Active Moderate-severe Graves' Orbitopathy NCT04876534 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | Phase 2 |
| Recruiting | Exploring Immunological Markers Associated With Mental Fatigue in Graves' Disease NCT05678374 | Vastra Gotaland Region | — |
| Unknown | Exophthalmometry With 3D Face Scanners NCT04704414 | University of Zurich | N/A |
| Completed | Study of RVT-1401 for the Treatment of Patients With Moderate to Severe Active Graves' Ophthalmopathy (GO) NCT03922321 | Immunovant Sciences GmbH | Phase 2 |
| Completed | Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy NCT03498417 | University of Pisa | — |
| Recruiting | Treatment of Graves´ophthalmopathy with Simvastatin (GO-S) NCT03131726 | Lund University | Phase 3 |
| Recruiting | Bimatoprost as a Treatment for Graves' Orbitopathy NCT03708627 | Johns Hopkins University | EARLY_Phase 1 |
| Completed | Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy NCT05793359 | Medical University of Sofia | — |
| Completed | Therapeutic Efficacy of Orbital Radiotherapy in Patients With Graves' Orbitopathy NCT05775185 | Medical University of Sofia | — |
| Completed | Glucocorticoids and Bone in Graves' Ophthalmopathy NCT03122847 | Torben Harsløf | — |
| Unknown | Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy NCT03066076 | Medical University of Vienna | Phase 3 |
| Completed | T and B Cells in Graves' Orbitopathy NCT03195296 | University of Pisa | — |
| Completed | Graves' Orbitopathy and Hypercholesterolemia NCT02721992 | University of Pisa | — |
| Completed | Analysis Between the Results of Two Surgical Techniques of Orbital Decompression in Patients With Graves Orbit NCT03278964 | University of Sao Paulo General Hospital | N/A |
| Unknown | Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease NCT02339142 | University of British Columbia | Phase 4 |
| Unknown | Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease NCT03324022 | National Taiwan University Hospital | — |
| Completed | Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) NCT02059655 | Cardiff University | Phase 4 |
| Unknown | Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy NCT02203682 | Sun Yat-sen University | Phase 2 |
| Unknown | Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People NCT02290704 | Sun Yat-sen University | — |
| Completed | Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy NCT01727973 | Sun Yat-sen University | Phase 1 / Phase 2 |
| Completed | Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) NCT01297699 | Hospital Clinico Universitario de Santiago | Phase 3 |
| Unknown | Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's Orbito NCT01999790 | University of Sao Paulo | N/A |
| Completed | Liver Function After Intravenous Methylprednisolone Administration NCT03667157 | Medical University of Warsaw | Phase 4 |
| Withdrawn | Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy NCT01379196 | Rabin Medical Center | Phase 1 / Phase 2 |
| Completed | Heart Rhythm After Intravenous Methylprednisolone Administration NCT04391439 | Medical University of Warsaw | — |
| Withdrawn | Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction NCT01272414 | University of Toronto | Phase 4 |
| Completed | Impact of Intravenous Methylprednisolone Treatment on Blood Pressure NCT03590080 | Medical University of Warsaw | — |
| Completed | Coagulation After Intravenous Methylprednisolone Administration NCT03535090 | Piotr Miskiewicz | — |
| Terminated | A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease NCT01114503 | GlaxoSmithKline | Phase 2 |
| Unknown | A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Grave NCT01969019 | Ruijin Hospital | Phase 4 |
| Unknown | The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy NCT01056419 | Ankara University | Phase 4 |
| Terminated | Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune Treatment NCT01893450 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | N/A |
| Completed | Color Doppler Imaging of Orbital Venous Flow in Grave's Orbitopathy NCT00697528 | University of Sao Paulo | — |
| Unknown | The Role of TSH Receptor, PPAR-r, IGF-1R, IGF and Cytokines in Different Stages of Graves'Ophthalmopathy NCT00174057 | National Taiwan University Hospital | — |
| Completed | Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies NCT00430547 | Barwon Health | N/A |
| Completed | Thyroid Treatment Trial NCT00348413 | Singapore National Eye Centre | N/A |