Trials / Unknown
UnknownNCT03324022
Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 80 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.
Conditions
Timeline
- Start date
- 2014-12-25
- Primary completion
- 2017-12-25
- Completion
- 2020-12-25
- First posted
- 2017-10-27
- Last updated
- 2017-10-31
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03324022. Inclusion in this directory is not an endorsement.