| Not Yet Recruiting | A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925 | Tetragon Biosciences Ltd | Phase 1 |
| Recruiting | Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Gliobla NCT06991101 | Baptist Health South Florida | Phase 2 |
| Recruiting | GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma NCT06815432 | Baylor College of Medicine | Phase 1 |
| Recruiting | Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoin NCT07179328 | Sunnybrook Health Sciences Centre | Phase 1 |
| Recruiting | Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma NCT06613841 | Abramson Cancer Center at Penn Medicine | EARLY_Phase 1 |
| Terminated | Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) NCT06193174 | University of Alabama at Birmingham | Phase 1 |
| Unknown | Cisplatin Plus Temozolomide Compared With Temozolomide in Patients With MGMT Promotor Unmethylated Glioblastom NCT06186440 | Zhongnan Hospital | Phase 1 / Phase 2 |
| Active Not Recruiting | Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme NCT05685004 | TVAX Biomedical | Phase 2 / Phase 3 |
| Active Not Recruiting | CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma NCT05627323 | Chimeric Therapeutics | Phase 1 |
| Recruiting | Intracavitary Photodynamic Therapy as an Adjuvant to Resection of Glioblastoma or Gliosarcoma Using IV Photoba NCT05363826 | Photolitec LLC | Phase 1 |
| Recruiting | Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) NCT05979064 | Northwell Health | N/A |
| Not Yet Recruiting | A Clinical Study of Intratumoral MVR-C5252 (C5252) in Patients With Recurrent or Progressive Glioblastoma NCT05095441 | ImmVira Pharma Co. Ltd | Phase 1 |
| Recruiting | The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) NCT06283927 | Jasper Gerritsen | — |
| Recruiting | The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma NCT06273176 | Erasmus Medical Center | — |
| Recruiting | The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202) NCT06146725 | Jasper Gerritsen | — |
| Terminated | Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial NCT04825275 | Milton S. Hershey Medical Center | EARLY_Phase 1 |
| Terminated | Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas NCT04869449 | Milton S. Hershey Medical Center | EARLY_Phase 1 |
| Completed | [18F]FPIA PET-CT in Glioblastoma Multiforme (GBM) NCT05801159 | Imperial College London | — |
| Unknown | The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors NCT05116137 | Nova Scotia Health Authority | N/A |
| Active Not Recruiting | Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma NCT05076513 | Nader Sanai | EARLY_Phase 1 |
| Active Not Recruiting | Safety & Efficacy of DC Vaccine and TMZ for the Treatment of Newly-diagnosed Glioblastoma After Surgery NCT04968366 | Beijing Tiantan Hospital | Phase 1 |
| Completed | Multi Peptide Vaccination with XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide C NCT04842513 | University Hospital Tuebingen | Phase 1 |
| Suspended | Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recu NCT04222309 | Northwell Health | Phase 1 |
| Active Not Recruiting | Trial of C134 in Patients With Recurrent GBM NCT03657576 | University of Alabama at Birmingham | Phase 1 |
| Recruiting | The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. NCT03861299 | Jasper Gerritsen | N/A |
| Completed | Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma NCT03665545 | University Hospital, Geneva | Phase 1 / Phase 2 |
| Unknown | Efficacy of Two Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma NCT03633552 | Mashhad University of Medical Sciences | Phase 3 |
| Enrolling By Invitation | Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme NCT03170141 | Shenzhen Geno-Immune Medical Institute | Phase 1 |
| Completed | Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme NCT03047473 | Clinique Neuro-Outaouais | Phase 2 |
| Active Not Recruiting | Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients NCT02649582 | University Hospital, Antwerp | Phase 1 / Phase 2 |
| Completed | Effect of Deep TMS on the Permeability of the BBB in Patients With Glioblastoma Multiforme: a Pilot Study NCT02474966 | University of Roma La Sapienza | Phase 2 |
| Unknown | MRSI to Predict Response to RT/TMZ ± Belinostat in GBM NCT02137759 | Emory University | Phase 2 |
| Completed | Ketogenic Diet Treatment Adjunctive to Radiation and Chemotherapy in Glioblastoma Multiforme: a Pilot Study NCT02302235 | Mid-Atlantic Epilepsy and Sleep Center, LLC | Phase 2 |
| Completed | Antineoplaston Therapy in Treating Patients With Newly-diagnosed Glioblastoma Multiforme NCT00003456 | Burzynski Research Institute | Phase 2 |