| Not Yet Recruiting | Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Dia NCT07452458 | NRG Oncology | Phase 3 |
| Not Yet Recruiting | Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas NCT07468136 | Mayo Clinic | Phase 1 / Phase 2 |
| Recruiting | GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Gliob NCT07301268 | Mayo Clinic | Phase 2 |
| Recruiting | A Study of 177Lu-PSMA-617 in People With Gliomas NCT07223034 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Recruiting | Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma NCT07091864 | Mayo Clinic | N/A |
| Recruiting | Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma NCT06419946 | Vastra Gotaland Region | Phase 3 |
| Terminated | Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promot NCT06359379 | Shuttle Pharmaceuticals, Inc. | Phase 2 |
| Recruiting | WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma NCT05879250 | Northwestern University | Phase 2 |
| Recruiting | Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide NCT04945148 | Hopital Foch | Phase 2 |
| Recruiting | Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, Th NCT06319027 | ECOG-ACRIN Cancer Research Group | Phase 2 |
| Recruiting | Evaluate the Efficacy and Safety of Atorvastatin Combined With Temozolomide in the Treatment of Glioblastoma NCT06327451 | Tianjin Medical University General Hospital | Phase 2 |
| Recruiting | Neoadjuvant Radio-chemotherapy Safety Pilot Study in Patients With Glioblastoma NCT06418113 | Hospital San Carlos, Madrid | Phase 1 |
| Recruiting | Stem Cell Analysis, Omics (Including Immunomics) and Artificial Intelligence in Glioblastoma NCT05941234 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma NCT05929495 | University of Milano Bicocca | Phase 2 |
| Recruiting | Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Meta NCT06047379 | Neonc Technologies, Inc. | Phase 1 / Phase 2 |
| Recruiting | Analyzing and Solving Exceptional Long-term Survivors in Solid Tumors With Poor Prognosis NCT06160596 | Cure 51 | — |
| Recruiting | Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma NCT05879367 | Orbus Therapeutics, Inc. | Phase 1 |
| Not Yet Recruiting | Elemene Plus Stupp Protocol Versus Stupp Protocol Alone for Newly-diagnosed Glioblastoma NCT05842746 | Peking Union Medical College Hospital | Phase 2 |
| Recruiting | THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERA NCT05326334 | Ottawa Hospital Research Institute | — |
| Recruiting | The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) NCT06283927 | Jasper Gerritsen | — |
| Recruiting | The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202) NCT06146725 | Jasper Gerritsen | — |
| Recruiting | The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) NCT06146738 | Jasper Gerritsen | — |
| Recruiting | The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma NCT06273176 | Erasmus Medical Center | — |
| Active Not Recruiting | Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma NCT05236036 | Northwestern University | Phase 1 |
| Completed | Regorafenib With Temozolomide With or Without RT in MGMT-Methylated, IDH Wild-type GBM Patients NCT06095375 | Istituto Oncologico Veneto IRCCS | Phase 1 |
| Recruiting | Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation NCT05271240 | Northwell Health | Phase 3 |
| Recruiting | The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 220 NCT06118723 | Jasper Gerritsen | — |
| Completed | BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and NCT05375318 | Juan M Garcia-Gomez | — |
| Completed | Biomolecular Analysis for Predicting Response to Regorafenib NCT05759195 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Active Not Recruiting | A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With NCT04145115 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Gliobl NCT04528680 | Northwestern University | Phase 1 / Phase 2 |
| Active Not Recruiting | WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Centr NCT04197934 | Mayo Clinic | Phase 1 |
| Completed | SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies fo NCT03434262 | St. Jude Children's Research Hospital | Phase 1 |