NCT07091864

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

Phase II Randomized Trial Of Glucose Monitoring In Glioblastoma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies whether continuous glucose monitoring (CGM) can be used to help patients with glioblastoma manage their blood sugar (glucose) levels and improve survival. Glioblastoma is the most common malignant primary brain tumor in adults, with an average survival time of approximately 15-18 months despite therapy. Studies have shown that having a higher-than-normal amount of glucose in the blood (hyperglycemia) during radiation therapy is associated with poorer survival outcomes in glioblastoma patients. Hyperglycemia in glioblastoma patients is often driven by steroids that are commonly used during treatment. CGM uses a device that places a sensor under the skin that monitors glucose levels at regular intervals, providing real-time, or near real-time, glucose information. This can help to identify when a patient has changes in their glucose levels so they may receive necessary interventions or medications sooner. CGM may be an effective way for glioblastoma patients to manage their glucose levels, which may improve survival.

Conditions

• Glioblastoma, IDH-Wildtype
• WHO Grade 4 Glioma

Interventions

Type	Name	Description
OTHER	Best Practice	Receive SOC treatment
PROCEDURE	Biospecimen Collection	Undergo blood sample collection
OTHER	Dietary Intervention	Attend dietary counseling sessions
OTHER	Glucose Measurement	Undergo intermittent glucose monitoring
PROCEDURE	Magnetic Resonance Imaging	Undergo MRI
OTHER	Monitoring	Undergo CGM
OTHER	Questionnaire Administration	Ancillary studies
OTHER	Supportive Care	Receive endocrinology-guided interventions

Timeline

• Start date: 2025-07-29
• Primary completion: 2027-11-30
• Completion: 2027-11-30
• First posted: 2025-07-29
• Last updated: 2025-11-10

Locations

1 site across 1 country: United States