| Withdrawn | Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids NCT05894109 | University of New Mexico | N/A |
| Completed | A Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A for Injection (CU-20101 NCT06585696 | Cutia Therapeutics(Wuxi)Co.,Ltd | Phase 3 |
| Completed | A Non-inferiority Clinical Trial to Compare Efficacy and Safety of Abobotulinumtoxin A (Espad Pharmed) Versus NCT06946160 | Espad Pharmed | Phase 3 |
| Completed | Phase 2a Study of DaxibotulinumtoxinA-lanm for Injection in Dynamic Forehead Lines and Glabellar Lines NCT06411002 | Revance Therapeutics, Inc. | Phase 2 |
| Completed | The Efficacy and Safety of Protoxin in Subjects With Moderate to Severe Glabellar Lines NCT06124794 | Protox Inc. | Phase 3 |
| Active Not Recruiting | Non Interventional Safety Study of NUCEIVA for the Treatment of Moderate-to-Severe Glabellar Lines NCT05481931 | Evolus, Inc. | — |
| Active Not Recruiting | Depth of Botulinum Neurotoxin Injection for Treatment of Glabellar Lines NCT05766683 | Henry Ford Health System | Phase 1 |
| Completed | The Efficacy and Safety Study of Protoxin Versus Botox® in Subjects With Moderate to Severe Glabellar Lines NCT05364580 | Protox Inc. | Phase 3 |
| Completed | Assess Aesthetic Improvement With QM1114-DP in Subjects With Moderate to Severe Lateral Canthal Lines and Glab NCT05148000 | Galderma R&D | Phase 3 |
| Unknown | Study to Compare the Efficacy and Safety of ATGC-110 (Botulinum Toxin) With Xeomin® for the Treatment of Moder NCT05623410 | ATGC Co., Ltd. | Phase 3 |
| Completed | AI-09 In Subjects With Glabellar Lines, GL-101 NCT05565950 | Eirion Therapeutics Inc. | Phase 1 / Phase 2 |
| Completed | Assess Aesthetic Improvement and Onset of QM1114-DP in Subjects With Moderate to Severe Glabellar Lines NCT05146999 | Galderma R&D | Phase 3 |
| Unknown | Xeomin Treatment of Glabellar Lines Using OLD Versus COLD NCT05305768 | Clinical Testing of Beverly Hills | EARLY_Phase 1 |
| Completed | Study to Demonstrate Safety and Duration of Effect of 40 Units of PrabotulinumtoxinA-xvfs to Treat Glabellar L NCT05320393 | Evolus, Inc. | Phase 2 |
| Completed | Long-term Extension Study to Evaluate MBA-P01 in Subjects With Moderate to Severe Glabellar Lines NCT05321979 | Medytox Korea | Phase 3 |
| Completed | Study Comparing Treatment With Alluzience vs Reconstituted Toxin NCT05277337 | Galderma R&D | Phase 4 |
| Completed | A Phase II Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Moderate to Severe Glabellar NCT05217355 | Medytox Korea | Phase 2 |
| Completed | Jeuveau Treatment of Glabellar Lines Using OLD Versus COLD NCT05129319 | Clinical Testing of Beverly Hills | EARLY_Phase 1 |
| Unknown | Duration of Botox Using OLD Versus COLD for Treatment of Glabellar Lines NCT05083286 | Clinical Testing of Beverly Hills | EARLY_Phase 1 |
| Completed | Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Glabellar Lines NCT05059587 | Medytox Korea | Phase 3 |
| Completed | Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventiona NCT05517538 | Mohamed Hayder Oleish Salih | N/A |
| Unknown | Split-Face Study Comparing Botox and Jeuveau in Treating Glabellar Lines NCT04715048 | University of Southern California | EARLY_Phase 1 |
| Completed | The Safety and Efficacy Study of PROTOXIN in Subjects With Moderate to Severe Glabellar Lines NCT04996810 | Protox Inc. | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety of Botulinum Toxin at Moderate to Severe Glabellar Lines NCT04830345 | EuBiologics Co.,Ltd | Phase 3 |
| Completed | Treatment of Moderate to Severe Glabellar Lines NCT04249583 | Galderma R&D | Phase 3 |
| Completed | A Comparative Study of Botulinum Neurotoxin Type A in Treatment of Moderate to Severe Glabellar Frown Lines NCT04281095 | ATGC Co., Ltd. | Phase 1 / Phase 2 |
| Unknown | Long-term Open-label Treatment of Moderate to Severe Glabellar Lines With CORETOX® NCT04281745 | Medy-Tox | Phase 4 |
| Completed | Efficacy and Safety of a New Dilution and Injection Volume of AbobotulinumtoxinA for the Treatment of Glabella NCT03960957 | Galderma R&D | Phase 3 |
| Completed | Clinical Trial to Evaluate the Efficacy and Safety of MBA-P01 in Treatment of Glabellar Lines NCT04143815 | Medy-Tox | Phase 2 |
| Completed | Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study III (BLESSIII) NCT03985982 | Croma-Pharma GmbH | Phase 3 |
| Completed | The Efficacy and Safety of CUNOX® in Patients With Moderate to Severe Glabellar Lines NCT03837561 | Medy-Tox | Phase 3 |
| Completed | Safety and Efficacy of AbobotulinumtoxinA for the Treatment of Glabellar Lines NCT03736928 | Galderma R&D | Phase 2 |
| Completed | Subject Satisfaction With AbobutulinumtoxinA Treatment NCT03687736 | Galderma R&D | Phase 4 |
| Unknown | The Safety and Efficacy Study of Hutox Versus Botox® in Subject With Moderate to Severe Glabellar Lines NCT03440671 | Huons Co., Ltd. | Phase 3 |
| Completed | Long-term Safety and Efficacy of MEDITOXIN® in Treatment Glabellar Lines NCT03289169 | Medy-Tox | Phase 4 |
| Completed | Safety of Single and Repeat Treatments of DaxibotulinumtoxinA for Injection for Treatment of Moderate to Sever NCT03004248 | Revance Therapeutics, Inc. | Phase 3 |
| Completed | Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines NCT03014622 | Revance Therapeutics, Inc. | Phase 3 |
| Completed | Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines NCT03014635 | Revance Therapeutics, Inc. | Phase 3 |
| Completed | Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study II NCT02677805 | Croma-Pharma GmbH | Phase 3 |
| Completed | Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study I NCT02677298 | Croma-Pharma GmbH | Phase 3 |
| Completed | Safety Study of DWP-450 (Botulinum Toxin, Type a) to Treat Glabellar Lines - EV-006 NCT02428608 | Evolus, Inc. | Phase 2 |
| Completed | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV-002 NCT02334436 | Evolus, Inc. | Phase 3 |
| Completed | A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001 NCT02334423 | Evolus, Inc. | Phase 3 |
| Completed | Efficacy and Safety of Botulinum Toxin Type A for Injection to Treat Glabellar Lines NCT02303002 | Revance Therapeutics, Inc. | Phase 2 |
| Completed | Safety and Efficacy Study of Botulinum Toxin for the Treatment of Glabellar Frown Lines NCT02236312 | Galderma R&D | Phase 2 |
| Completed | Safety Study of DWP-450 (Botulinum Purified Neurotoxin, Type A) Injection to Treat Glabellar Lines NCT02184988 | Evolus, Inc. | Phase 2 |
| Completed | A Safety and Efficacy Study of Different Injections Volumes of Botulinum Toxin Type A, Azzalure, in the Glabel NCT02108158 | Galderma R&D | Phase 4 |
| Completed | The Treatment of Glabellar Frown Lines NCT02096081 | Merz North America, Inc. | Phase 4 |
| Completed | Efficacy and Safety Study of MT10107 in the Treatment of Glabella Line NCT03908008 | Medy-Tox | Phase 3 |
| Completed | A Prospective Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the Cryo-Touch IV Device NCT01801826 | Pacira Pharmaceuticals, Inc | — |
| Completed | Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the CRYO-TOUCH III Device NCT01808742 | Pacira Pharmaceuticals, Inc | — |
| Completed | Safety and Efficacy Study of Botulinum Toxin Type A to Treat Glabellar Lines NCT01485601 | Medy-Tox | Phase 2 |
| Completed | Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines NCT01391312 | Allergan | Phase 4 |
| Completed | Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Forehead and Frown Lines NCT01391299 | Allergan | N/A |
| Completed | Safety and Efficacy Study of Dysport RU and Glabellar Lines NCT01333397 | Ipsen | Phase 2 |
| Completed | NT 201 (Xeomin®/Bocouture®) in Comparison With Clostridium Botulinum Toxin Type A in the Treatment of Glabella NCT00777803 | Merz Pharmaceuticals GmbH | Phase 3 |
| Completed | Finding of Optimal Dose for NT 201 in the Treatment of Glabellar Frown Lines NCT00430586 | Merz Pharmaceuticals GmbH | Phase 2 |
| Completed | IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Glabellar Frown Lines NCT00430963 | Merz Pharmaceuticals GmbH | Phase 3 |