| Not Yet Recruiting | CAP-TEER: CerebrAl Protection During Transcatheter Edge-to-edge Repair NCT06814210 | Xiao-dong Zhuang | N/A |
| Recruiting | Safety and Effectiveness Study of SQ-Kyrin System for Functional Mitral Regurgitation in EU NCT06823700 | Shanghai Shenqi Medical Technology Co., Ltd | N/A |
| Recruiting | Bio Refine for Functional Mitral Regurgitation - a Safety & Feasibility Study NCT06583876 | Bio Refine Ltd. | N/A |
| Active Not Recruiting | Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitatio NCT05991284 | Ziekenhuis Oost-Limburg | Phase 4 |
| Recruiting | Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation NCT05920824 | Barts & The London NHS Trust | — |
| Not Yet Recruiting | Epicardial Mitral Touch System for Mitral Insufficiency NCT04396379 | Mitre Medical Corp. | N/A |
| Recruiting | Phenotypic Classification of FMR With CMR NCT05965258 | The Cleveland Clinic | — |
| Unknown | The JensClip Transcatheter Valve Repair System for Treating Functional Mitral Regurgitation NCT05931900 | Jenscare Scientific | N/A |
| Unknown | Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Fibrosis (DEFORM) NCT05848102 | Sun Yat-sen University | Phase 4 |
| Unknown | Treatment of Moderate FMR During AVR NCT05566340 | Fuwai Yunnan Cardiovascular Hospital | — |
| Unknown | Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Remodeling NCT05606718 | Sun Yat-sen University | Phase 4 |
| Active Not Recruiting | Safety and Effectiveness Study of SQ-Kyrin TMVr System for Functional Mitral Regurgitation NCT05988450 | Shanghai Shenqi Medical Technology Co., Ltd | N/A |
| Recruiting | Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance NCT07131631 | Minneapolis Heart Institute Foundation | — |
| Completed | Fate of Moderate Secondary Mitral Regurgitation in Patients Undergoing Aortic Valve Surgery for Severe Aortic NCT05774808 | Michele De Bonis | — |
| Withdrawn | Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurgitation ( EXP NCT04666467 | Polares Medical SA | N/A |
| Unknown | Biomechanical Taping on Low Back Pain With Increased Foot Pronation NCT04776798 | Istanbul University - Cerrahpasa | N/A |
| Not Yet Recruiting | EXPLORE FMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Functional Mitral Regurg NCT04679714 | Polares Medical SA | N/A |
| Terminated | An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitat NCT04529928 | Cardiac Dimensions Pty Ltd | N/A |
| Completed | MitraClip Russia Trial NCT04350372 | Abbott Medical Devices | N/A |
| Completed | PASCAL vs. MitralClip for Mitral Valve Transchatheter Edge-to-Edge Repair NCT05865938 | Heinrich-Heine University, Duesseldorf | — |
| Active Not Recruiting | NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study NCT03929913 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Unknown | VenTouch OUS Feasibility Study NCT03616678 | Mardil Medical | N/A |
| Active Not Recruiting | Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial NCT03706833 | Edwards Lifesciences | N/A |
| Active Not Recruiting | Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System NCT03433274 | Abbott Medical Devices | N/A |
| Recruiting | The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR NCT03142152 | Cardiac Dimensions, Inc. | N/A |
| Completed | The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (B NCT03228381 | Mardil Medical | N/A |
| Enrolling By Invitation | The CINCH-FMR Post-Market Registry: Percutaneous Repair in Functional Mitral Regurgitation NCT05677568 | Cardiac Dimensions, Inc. | — |
| Terminated | Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE) NCT03016975 | Edwards Lifesciences | N/A |
| Withdrawn | Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regur NCT02985268 | Montreal Heart Institute | N/A |
| Unknown | Evaluation of Safety and Efficacy of the BACE™ Device in the Treatment of Functional Mitral Valve Regurgitatio NCT02701972 | Phoenix Cardiac Devices, Inc. | N/A |
| Unknown | Evaluation of the Minimally Invasive VenTouch™ System in the Treatment of Functional Mitral Valve Regurgitatio NCT02671799 | Mardil Medical | N/A |
| Completed | AVJ-514 Japan Trial NCT02520310 | Abbott Medical Devices | N/A |
| Completed | Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation NCT02471664 | Tau-MEDICAL Co., Ltd. | N/A |
| Completed | Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function NCT01899573 | Ancora Heart, Inc. | N/A |
| Completed | Mitralign Percutaneous Annuloplasty First in Man Study NCT01852149 | Mitralign, Inc. | N/A |
| Terminated | Plasty or Prosthesis to Treat Functional Mitral Regurgitation NCT00947921 | Cardiochirurgia E.H. | N/A |
| Completed | A Study of Percutaneous Repair of Functional Mitral Regurgitation Using the Ancora Heart, Inc. AccuCinch® Vent NCT00800046 | Ancora Heart, Inc. | N/A |