| Recruiting | An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis NCT06557733 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP) NCT06641310 | University of Michigan Rogel Cancer Center | N/A |
| Recruiting | Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 NCT05630794 | National Cancer Institute (NCI) | Phase 1 |
| Not Yet Recruiting | Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis NCT06308445 | University Hospital, Toulouse | Phase 2 |
| Recruiting | Ten Versus Fifteen Centimeter Pouch in IPAA Surgery NCT06538402 | Odense University Hospital | N/A |
| Recruiting | Microbial and Environmental Factors Associated with Polyps Development in Familial Adenomatous Polyposis (Micr NCT06614738 | Hospices Civils de Lyon | — |
| Recruiting | Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis NCT06578637 | Abramson Cancer Center at Penn Medicine | N/A |
| Recruiting | Chemopreventive Effect of Combination of Celecoxib and Metformin in Patients With Familial Adenomatous Polypos NCT06545526 | Yonsei University | Phase 3 |
| Recruiting | Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous NCT06435533 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Recruiting | Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) NCT05552755 | Recursion Pharmaceuticals Inc. | Phase 1 / Phase 2 |
| Completed | Visualization of the Papilla Through Use of the NuView Device in Patients With FAP NCT05657145 | Vanderbilt University Medical Center | — |
| Suspended | Testing Obeticholic Acid for Familial Adenomatous Polyposis NCT05223036 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Inherited Cancer Early Diagnosis (ICED) Study NCT06163365 | Royal Marsden NHS Foundation Trust | — |
| Completed | The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis NCT05402891 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2 |
| Recruiting | A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Ha NCT04678011 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | Review of Post-Study Clinical Endoscopy Reports in Follow Up to MAY2016-07-01 NCT04674228 | National Cancer Institute (NCI) | — |
| Unknown | DNA Adductomics for Colorectal Cancer Investigation NCT04865601 | University of Copenhagen | — |
| Active Not Recruiting | Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance NCT04230499 | Rapamycin Holdings Inc. | Phase 2 |
| Recruiting | A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Fami NCT04677998 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Not Yet Recruiting | Colorectal Adenoma Canceration in FAP NCT04531930 | Changhai Hospital | — |
| Unknown | Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis NCT04454151 | Tel-Aviv Sourasky Medical Center | Phase 4 |
| Unknown | Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses NCT04709445 | Charite University, Berlin, Germany | N/A |
| Unknown | Niclosamide for Familial Adenomatous Polyposis NCT04296851 | Yonsei University | Phase 2 |
| Active Not Recruiting | CryoBalloon Ablation for Treatment of Duodenal Adenomas NCT03847636 | Johns Hopkins University | N/A |
| Unknown | Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-ana NCT04695964 | Charite University, Berlin, Germany | N/A |
| Unknown | Subjective Near-infrared Fluorescence Guidance in Perfusion Assessment of Ileal Pouch Formation and Ileal-pouc NCT04695184 | Charite University, Berlin, Germany | N/A |
| Active Not Recruiting | Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis NCT03806426 | S.L.A. Pharma AG | Phase 3 |
| Recruiting | Duodenal Polyposis Classification in FAP NCT07199127 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | — |
| Completed | Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at R NCT02961374 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Cold Snare Polypectomy for Duodenal Adenomas in Familial Adenomatous Polyposis NCT03471403 | Western Sydney Local Health District | — |
| Recruiting | Familial Investigations of Childhood Cancer Predisposition NCT03050268 | St. Jude Children's Research Hospital | — |
| Unknown | Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis. NCT03061591 | Tel-Aviv Sourasky Medical Center | Phase 2 |
| Terminated | 18F-FES PET/CT in Imaging Patients With Desmoid Tumors NCT02374931 | Vanderbilt-Ingram Cancer Center | EARLY_Phase 1 |
| Unknown | Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP) NCT02656134 | University of Sao Paulo | — |
| Completed | Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes NCT02198092 | University of Pennsylvania | — |
| Recruiting | Integrated Cancer Repository for Cancer Research NCT02012699 | University of Nebraska | — |
| Completed | Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP) NCT01483144 | Cancer Prevention Pharmaceuticals, Inc. | Phase 3 |
| Completed | The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Random NCT01725490 | Yonsei University | Phase 2 |
| Withdrawn | A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) NCT01245816 | Cancer Prevention Pharmaceuticals, Inc. | Phase 3 |
| Completed | Curcumin in Treating Patients With Familial Adenomatous Polyposis NCT00641147 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Single Incision Laparoscopic Surgery in Treating Patients With Colorectal Disease NCT01656746 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis NCT00808743 | Radboud University Medical Center | Phase 2 / Phase 3 |
| Terminated | Endomicrocancer: Confocal Endomicroscopy in Patients With High Risk of Colorectal Cancer NCT01052376 | Nantes University Hospital | N/A |
| Terminated | Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses NCT00663819 | W.L.Gore & Associates | N/A |
| Completed | Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP) NCT00927485 | University of Puerto Rico | N/A |
| Completed | Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP) NCT00525655 | M.D. Anderson Cancer Center | N/A |
| Completed | Lyophilized Black Raspberries in Adults With Familial Adenomatous Polyposis (FAP) NCT00770991 | The Cleveland Clinic | Phase 1 |
| Unknown | Adenoma Detection Rate:NBI, AFI, Chromoscopic or Standard Endoscopy NCT00253812 | London North West Healthcare NHS Trust | N/A |
| Withdrawn | Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients NCT00248053 | Johns Hopkins University | Phase 2 |
| Completed | Endoscopic Papillectomy for Ampullary Adenomas NCT03494543 | Azienda USL Reggio Emilia - IRCCS | — |
| Completed | Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers NCT00503035 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous P NCT00033371 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Is Diverting Ileostomy Necessary in Stapled Ileoanal Pouch? NCT01173250 | Mansoura University | N/A |