Trials / Unknown
UnknownNCT02656134
Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)
Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis: A Prospective Clinical, Immunopathologic and Molecular Analysis
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 55 (estimated)
- Sponsor
- University of Sao Paulo · Academic / Other
- Sex
- All
- Age
- 15 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
Background and study aim The relative risks of duodenal adenocarcinoma and ampullary carcinoma in Familial Adenomatous Polyposis (FAP) have been estimated 100 to 330 times higher than in general population. However risk factors, including a genotype-phenotype association for duodenal cancer in FAP has not been fully understood. The aim of this study is to determine risk factors associated with the development of advanced duodenal polyposis and ampullary adenomas in colectomized patients with FAP.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Duodenoscopy and enteroscopy | All patients will undergo duodenoscopy and classified according to Spigelman. Patients classified as Spigelman III and IV will undergo enteroscopy. |
| GENETIC | Molecular analysis. | DNA analysis |
Timeline
- Start date
- 2015-03-01
- Primary completion
- 2016-09-01
- Completion
- 2016-12-01
- First posted
- 2016-01-14
- Last updated
- 2016-01-14
Locations
1 site across 1 country: Brazil
Source: ClinicalTrials.gov record NCT02656134. Inclusion in this directory is not an endorsement.