| Not Yet Recruiting | A Multi Center Study Testing a New Implant for Adults With Severe Emphysema NCT07119229 | Pulmair Medical, Inc. | N/A |
| Not Yet Recruiting | Utilising Hull Lung Health Study Data to Investigate the Performance of TidalSense Diagnostic Algorithms to Id NCT06788613 | Chiesi UK | — |
| Recruiting | PiMZ Longitudinal Cohort (PiMZ Logic) NCT06505603 | Columbia University | — |
| Recruiting | The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema NCT06655428 | Morair Medtech, LLC | N/A |
| Withdrawn | Maximizing Benefit of Lung Cancer Screening Incidental Findings of Cardiovascular, Respiratory and Breast Meas NCT05900544 | University of Montana | N/A |
| Completed | Anti-Platelets in Chronic Obstructive Pulmonary Disease NCT05567562 | Brigham and Women's Hospital | Phase 2 |
| Recruiting | An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emph NCT06035120 | Pulmonx Corporation | N/A |
| Recruiting | Airway Bypass - Safety and Feasibility Study NCT06249529 | Zoar Engelman | EARLY_Phase 1 |
| Recruiting | The Effect of Treatment of Emphysema With Endobronchial Valves on the Diaphragm Mobility NCT06163131 | Aarhus University Hospital | — |
| Completed | RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection NCT06149494 | Altesa Biosciences, Inc. | Phase 2 |
| Recruiting | Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease NCT06304207 | MGH Institute of Health Professions | N/A |
| Active Not Recruiting | Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema NCT05949645 | Apreo Health, Inc. | N/A |
| Completed | First in Human Study to Assess an Implant to Treat Severe Emphysema NCT05854550 | Apreo Health, Inc. | N/A |
| Recruiting | Ultrasound and Respiratory Physiological Signals in Lung Diseases NCT06068647 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Healthy At Home Pilot NCT06000696 | University of Massachusetts, Worcester | — |
| Recruiting | Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction NCT05257681 | Beth Israel Deaconess Medical Center | N/A |
| Withdrawn | Introduction of the Vapor Treatment in The Netherlands NCT04029077 | University Medical Center Groningen | — |
| Recruiting | Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema NCT04801108 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Evaluation of the Free Flow Medical Lung Tensioning Device System for the Treatment of Severe Emphysema NCT04520152 | University Medical Center Groningen | N/A |
| Unknown | LVRS Versus BLVR in Patients With Homogenous Emphysema, CLUB-HE Trial NCT04781582 | Universität Duisburg-Essen | N/A |
| Recruiting | Biological Investigation of Explanted Endobronchial Lung Valves Study NCT04214587 | University Medical Center Groningen | — |
| Completed | Zephyr Etude Post-Inscription (French Registry) NCT04517916 | Pulmonx Corporation | — |
| Completed | Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency NCT03679598 | University of Alabama at Birmingham | Phase 2 |
| Unknown | The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) NCT03755505 | Asan Medical Center | — |
| Completed | A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchosco NCT03670121 | Uptake Medical Technology, Inc. | N/A |
| Recruiting | Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure NCT03500731 | Paul Szabolcs | Phase 1 / Phase 2 |
| Recruiting | Post-Market BTVA Registry NCT03318406 | Uptake Medical Technology, Inc. | — |
| Completed | Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia NCT03205826 | University Medical Center Groningen | N/A |
| Unknown | The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation NCT03285100 | Canisius-Wilhelmina Hospital | — |
| Unknown | Steroid Resistance During COPD Exacerbations With Respiratory Failure NCT03680495 | University of Colorado, Denver | — |
| Withdrawn | Crossover Blinded Trial of Cell Therapy Versus Placebo in COPD NCT03228121 | Lung Institute | N/A |