NCT03755505

The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Extensive studies suggest composition of microbiome of respiratory samples or lung tissues in COPD patients is different from the composition of healthy smokers. Aim of this study is to analyze composition of microbiome of various samples (e.g. feces, sputum, and urine) and to describe difference of composition between COPD patients and healthy smokers.

Detailed description

After the introduction of the Gut-Lung axis theory, extensive studies revealed diversity of microbiomes among healthy smokers and COPD patients form the respiratory samples or lung tissues. In the previous study, distinct difference in composition of microbiome in lung tissue between healthy smokers and COPD patients was reported. This is a cross sectional study to analyze composition of microbiome of various samples (e.g. feces, sputum, and urine) and to compare difference of composition between COPD patients and healthy smokers. This study would help establishing gut-lung axis model in humans.

Conditions

• Pulmonary Disease, Chronic Obstructive
• Emphysema or COPD
• Microbiota

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	obtain samples from sputum, feces and urine	Samples are obtained from participants. No further intervention is required. Obtained samples will be further analyzed.

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-03-31
• Completion: 2019-09-30
• First posted: 2018-11-28
• Last updated: 2018-11-28

Locations

1 site across 1 country: South Korea