| Not Yet Recruiting | Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries NCT07393087 | Centre Hospitalier Universitaire Vaudois | N/A |
| Not Yet Recruiting | MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients NCT06308926 | MedRegen LLC | Phase 2 |
| Recruiting | Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis NCT06491966 | Sichuan Provincial People's Hospital | — |
| Active Not Recruiting | Anakinra in Dengue With Hyperinflammation ( AnaDen ) NCT05611710 | Oxford University Clinical Research Unit, Vietnam | Phase 2 |
| Completed | Interleukin-34 in Stage I and II Periodontitis NCT06052774 | Ain Shams University | N/A |
| Withdrawn | CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 NCT04378244 | Aveni Foundation | Phase 1 / Phase 2 |
| Unknown | Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis NCT05491304 | The Children's Hospital of Zhejiang University School of Medicine | Phase 4 |
| Completed | Relationship Between Oral Findings and Salivary Factors in Sars-Cov-2 Patients NCT05476848 | Ege University | N/A |
| Unknown | CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock NCT05136183 | Mahidol University | N/A |
| Withdrawn | Anakinra, COVID-19, Cytokine Storm NCT04603742 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult NCT05013034 | Fort Worth Clinical Sciences Working Group | Phase 2 |
| Unknown | Non-invasive Nervus Vagus Stimulation in Patients With COVID-19 and ARDS NCT05058742 | Vienna Hospital Association | N/A |
| Completed | UNITE Study (UMN-SW) for COVID-19 NCT04854798 | University of Minnesota | N/A |
| Completed | Menstrual Blood Stem Cells in Severe Covid-19 NCT05019287 | Avicenna Research Institute | Phase 1 / Phase 2 |
| Completed | Prospective Study for the Application of Cytosorb® in Critically Ill Patients NCT04913298 | Ludwig-Maximilians - University of Munich | N/A |
| Withdrawn | High-Dose Corticosteroid or Tocilizumab for Clinical Worsening of COVID-19 NCT05133635 | Marmara University | Phase 4 |
| Completed | Intercellular Adhesion Molecule-1 and TNF-α in Patients With COVID-19 NCT05408325 | Benha University | — |
| Completed | UNITE Study (UMN-GE) for COVID-19 NCT04701489 | University of Minnesota | N/A |
| Completed | Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart F NCT06003972 | Hadassah Medical Organization | Phase 2 |
| Completed | Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes NCT06390748 | Lin Chen | Phase 2 |
| Completed | Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection NCT04739345 | Ain Shams University | N/A |
| Completed | Comparison of Tocilizumab Versus Tocilizumab/Infliximab in Patients With COVID-19-associated Cytokine Storm Sy NCT04734678 | Ain Shams University | — |
| Completed | Clinical Outcomes of High Dose Vitamin D Versus Standard Dose in COVID-19 Egyptian Patients NCT04738760 | Ain Shams University | — |
| Completed | Inflammatory Response to Opioid Versus Opioid Free Anesthesia NCT04854252 | University of Guadalajara | N/A |
| Completed | Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine NCT04798677 | AB Biotek | N/A |
| Completed | The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People NCT04476745 | Applied Science Private University | N/A |
| Completed | The Effect of Omega-3 on Selected Cytokines Involved in Cytokine Storm NCT04483271 | Applied Science Private University | N/A |
| Suspended | Cytokine Adsorption in Patients With Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation NCT04385771 | Dr. Alexander Supady | N/A |
| Completed | Immune Response Following COVID-19 in Hemodialysis Patients NCT05307601 | AURA Paris | — |
| Unknown | Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients NCT04517162 | Janette Furuzawa Carballeda | Phase 1 / Phase 2 |
| Unknown | Yoga Pranayama Adjuvant to Treat Burden COVID-19 NCT04413747 | Health Ricerca e Sviluppo S.R.L. | N/A |
| Completed | Early Treatment of Cytokine Storm Syndrome in Covid-19 NCT04362111 | University of Alabama at Birmingham | Phase 3 |
| Terminated | Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Impr NCT04433546 | PhaseBio Pharmaceuticals Inc. | Phase 2 |
| Withdrawn | RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM NCT04433078 | Temple University | Phase 2 |
| Unknown | Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia NCT04753476 | Stem Cell and Cancer Research Indonesia | Phase 2 |
| Terminated | Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 NCT04327505 | Karolinska Institutet | Phase 2 / Phase 3 |
| Terminated | A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to NCT04415073 | Syndax Pharmaceuticals | Phase 2 |
| Completed | Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome NCT04366908 | Maimónides Biomedical Research Institute of Córdoba | Phase 2 |
| Completed | Fluoxetine to Reduce Intubation and Death After COVID19 Infection NCT04377308 | University of Toledo Health Science Campus | Phase 4 |
| Suspended | Ultra Low Doses of Therapy With Radiation Applicated to COVID-19 NCT04394182 | Fundacion GenesisCare | N/A |
| Unknown | Dexmedetomidine to Improve Outcomes of ARDS in Critical Care COVID-19 Patients NCT04358627 | Hospital Clinic of Barcelona | — |
| Completed | Cytokine Adsorption in Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation NCT04324528 | Dr. Alexander Supady | N/A |
| Unknown | Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19 NCT04306705 | Tongji Hospital | — |
| Unknown | Early Haemadsorption in Major Burns NCT04195126 | University of Pecs | N/A |
| Completed | Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resus NCT03685383 | University Hospital Freiburg | N/A |
| Completed | Influence of Cytosorb on Amount of Catecholamine and Mortality in Sepsis NCT04567199 | Medical University Innsbruck | — |
| Completed | Cytokine Hemoadsorption in ECMO Patients NCT04901338 | University Medical Centre Ljubljana | — |
| Completed | Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis. NCT04226430 | University of Gaziantep | — |
| Completed | Cytokine Adsorption in Severe, Refractory Septic Shock NCT04910893 | University of Zurich | N/A |
| Completed | Keratinocyte Growth Factor and Cytokines in Burns. NCT01302223 | Federal University of São Paulo | — |
| Completed | Blood Transfusions and Immune Response NCT02020525 | Aretaieion University Hospital | N/A |
| No Longer Available | Expanded Access for Use of bmMSC-Derived Extracellular Vesicles in Patients With COVID-19 Associated ARDS NCT04657458 | Direct Biologics, LLC | — |