Trials / Completed
CompletedNCT02020525
Blood Transfusions and Immune Response
The Impact of Lowering Transfusion Trigger on Patient Immune Response During Major Abdominal Surgery
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 58 (actual)
- Sponsor
- Aretaieion University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
* We have previously reported the results of the primary and secondary outcomes of a randomized study aiming to investigate the impact of a restrictive transfusion protocol on the magnitude of reduction in blood transfusion in a typically mixed general surgery population subjected to major abdominal surgery. * The main finding of that study was a reduction in red blood cell usage with the implementation of a restrictive transfusion regimen. This was achieved without adversely affecting clinical outcome in the population studied. * The aim of this secondary analysis performed on a subgroup of 20 patients from the original study was to determine whether there are any differences in the postoperative immunologic response, as expressed by the production of inflammatory mediators, between a restrictive approach to red cell transfusion and a more liberal strategy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | restrictive transfusion strategy | Patients allocated to the restrictive transfusion strategy were transfused only when their hemoglobin concentration decreased below 7.7 g d dL-1 and were then maintained at hemoglobin concentrations between 7.7 and 9.9 g d dL-1. |
| PROCEDURE | liberal transfusion strategy | Patients assigned to the liberal strategy were transfused when their hemoglobin concentration fell below 9.9 g dL-1, aiming at maintaining hemoglobin at or above 10 g dL-1. |
Timeline
- Start date
- 2004-12-01
- Primary completion
- 2007-05-01
- Completion
- 2007-05-01
- First posted
- 2013-12-25
- Last updated
- 2019-02-15
Locations
1 site across 1 country: Greece
Source: ClinicalTrials.gov record NCT02020525. Inclusion in this directory is not an endorsement.