| Recruiting | VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) NCT06456268 | Columbia University | N/A |
| Not Yet Recruiting | This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and NCT07264829 | Dow University of Health Sciences | N/A |
| Not Yet Recruiting | Cryoanalgesia and Post-thoracotomy Pain in Minimally Invasive Cardiothoracic Surgery NCT05255146 | University of Alberta | N/A |
| Recruiting | Percutaneous Intercostal Cryoneuromodulation Onset Timing. NCT07081620 | Papa Giovanni XXIII Hospital | — |
| Completed | Cryotherapy on Muscle Function NCT06970366 | Okan University | N/A |
| Recruiting | Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With Stable Angina or ACS - NCT06939374 | Cryotherapeutics SA | N/A |
| Not Yet Recruiting | Acute Effects of Cryotherapy on Muscle Properties NCT06608836 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | Utility of Intermittent Cryo-Compression Versus Traditional Icing Following Arthroscopic Rotator Cuff Repair NCT05095909 | Allina Health System | N/A |
| Not Yet Recruiting | A Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of Melasma NCT06491771 | Mahidol University | N/A |
| Recruiting | National Registry of Surgical Treatment and Percutaneous Cryoablation of Parietal Endometriosis NCT06356831 | Centre Hospitalier Intercommunal Creteil | — |
| Completed | Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection NCT05896150 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | Intercostal Cryoanalgesia for Chronic Pain After VATS Lung Resection NCT05884099 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Unknown | Effect of Cryolipolysis on Insulin Resistance NCT06223490 | Cairo University | N/A |
| Unknown | Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchath NCT06293209 | Thai Traditional Medical Knowledge Fund | N/A |
| Completed | Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament NCT06629285 | University Medical Center Ho Chi Minh City (UMC) | Phase 2 / Phase 3 |
| Completed | The Effect of Brief Skin Cooling on Isometric Muscle Strength NCT06079437 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | N/A |
| Completed | Cooling Induces Motor Facilitation With Sympathetic Activation NCT05832970 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | N/A |
| Unknown | Cryotherapy Post-haemorrhoidectomy (CYPHER) Randomized Controlled Trial NCT06005727 | Singapore General Hospital | N/A |
| Recruiting | Evaluation of Cryotherapy in Granuloma Pyogenicum NCT05692427 | Medical University of Graz | N/A |
| Unknown | Cryotherapy Efficacy During Pulp Therapy of the Mandibular First Permanent Molars in Children NCT05441995 | Minia University | N/A |
| Completed | Acute Effects of Cryotherapy Duration in Healthy Individuals NCT05355584 | Burcu Camcıoğlu Yılmaz | N/A |
| Active Not Recruiting | Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With (N)STEMI or Unstable A NCT05600088 | Cryotherapeutics SA | N/A |
| Completed | Cryocompression After Total Knee Arthroplasty NCT05395273 | University of Applied Sciences and Arts of Southern Switzerland | N/A |
| Completed | Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment NCT05476445 | Ataturk University | N/A |
| Active Not Recruiting | Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection NCT05348447 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Unknown | Observation of the Comfort and Efficacy of CO2 Laser Combined With Cryo 6 for Burn or Linear Scars. NCT05555602 | Kaiyang Lv, MD-PhD | N/A |
| Completed | Lung Cancer Cryo-Activation as a Novel Approach to Augment Immunotherapy Efficacy (CRYOVATE) NCT04793815 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery NCT04710277 | Ohio State University | N/A |
| Completed | Cost-effectiveness of EndWarts® FREEZE - an Alternative Home Cryotherapy Device for Wart Treatment NCT04781244 | Mahidol University | N/A |
| Completed | Evaluation of Efficacy of Cryotherapy for Skin Anesthesia During Arterial Puncture NCT03973385 | Versailles Hospital | N/A |
| Active Not Recruiting | Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery NCT05011084 | Walter Reed National Military Medical Center | N/A |
| Recruiting | Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in 1st-line Treatment for P NCT04339218 | Institut Bergonié | Phase 3 |
| Terminated | The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Brea NCT04558034 | Parkview Health | N/A |
| Completed | Body Cooling in Hyperthermic Males and Females NCT04190264 | University of North Carolina, Greensboro | N/A |
| Unknown | Does Ice Cream Help With Post-tonsillectomy Pain NCT04164511 | University Hospital Sestre Milosrdnice | — |
| Completed | Rate of Tissue Temperature Reduction Between Wetted Ice and Game Ready NCT04019392 | North Dakota State University | N/A |
| Completed | Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors NCT06531265 | Sohag University | N/A |
| Completed | Comparison of Different Forms of Recovery on the Functionality After Physical Exercise NCT04201977 | Universidade Federal de Santa Maria | N/A |
| Completed | Cryoanalgesia for Arterial Puncture Pain NCT05251688 | Mansoura University | N/A |
| Completed | Intraoral Cryotherapy in Root Canal Retreatment NCT05091554 | Izmir Katip Celebi University | N/A |
| Completed | Effect of Motorized Cryotherapy on Early Effusion, Swelling, and Pain After Anterior Cruciate Ligament Reconst NCT04222933 | Hanyang University Seoul Hospital | N/A |
| Completed | Compressive Cryotherapy Versus Conventional Cryotherapy After Total Knee Arthroplasty NCT06037824 | Institut de Formation en Masso-Kinésithérapie Saint Michel | N/A |
| Completed | Efficacy of an Investigational Thermal Rehab Machine on Body Cooling in Hyperthermic Individuals NCT03643835 | University of North Carolina, Greensboro | N/A |
| Unknown | Effects of Cold Application on Exercise Performance NCT03776734 | Eastern Mediterranean University | N/A |
| Completed | Abdominal Ice Packs for Pain Control and Reduction of Narcotic Use Following Laparoscopic Hysterectomy NCT03341533 | Mayo Clinic | N/A |
| Completed | Aerobic Exercise Program Followed by Cold Water Immersion: Effects on Arthritis Patients Arterial Stiffness NCT03911830 | Centre Hospitalier Universitaire de Besancon | N/A |
| Completed | Cryotherapy and Body Slimming NCT04287153 | Clinic Cryo Esthetic | N/A |
| Completed | Cryoprotection of Chemotherapy-induced Oral Mucositis After Autologous Stem Cell Transplantation, a Randomized NCT03203733 | Uppsala University | N/A |
| Completed | Effect on Dynamic Postural Stability After Application of Cryotherapy to the Knee Joint NCT03151031 | Asir John Samuel | N/A |
| Completed | The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects NCT03185507 | University of Virginia | Phase 1 |
| Completed | Safety and Feasibility Study of Rejuvenair™ for Treating Chronic Bronchitis Patients NCT02483637 | CSA Medical, Inc. | N/A |
| Completed | Different Cold Application Times on Ecchmosis, Edema and Pain After Rhinoplasty NCT04512664 | University of Beykent | N/A |
| Completed | Behaviour After Exercise of Biological, Clinical and Metabolic Variables as From Different Temperatures and Ti NCT02497495 | Paulista University | N/A |
| Completed | The Effects of Cold Water Immersion With Different Dosages (Duration and Temperature Variations) on Heart Rate NCT02499640 | Paulista University | N/A |
| Unknown | Cryotherapy Against Oral Mucositis After High-dose Melphalan NCT03704597 | Sahlgrenska University Hospital | N/A |
| Completed | Cold Therapy in the Treatment of Exercise-induced Muscle Damage NCT02341612 | University of Brasilia | N/A |
| Completed | Anti Inflammatory Effects of Local Cryotherapy in Knee Arthritis NCT03850392 | Centre Hospitalier Universitaire de Besancon | N/A |
| Completed | Analysis of Neuromuscular Responses and the Balance After the Application of Physiotherapy Resources NCT02089022 | University of Sao Paulo | N/A |
| Completed | Clinical Efficacy of Cryolipolysis on the Fat of Thigh in Korean Women NCT01177787 | Wonik Trade Company, Korea | N/A |
| Completed | Effects of Cold Application and Heparinoid on Periorbital Edema and Ecchymosis NCT04119297 | Necmettin Erbakan University | N/A |