| Not Yet Recruiting | EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization NCT07313800 | Cortex Neurovascular | N/A |
| Not Yet Recruiting | Suppressive Functions of Regulatory T Cells in Migraine NCT07067112 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine NCT07018713 | Merz Therapeutics GmbH | Phase 3 |
| Not Yet Recruiting | Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood NCT07033520 | Fundación Cardiovascular de Colombia | N/A |
| Recruiting | Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine NCT06974617 | Cairo University | N/A |
| Recruiting | Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine NCT06795867 | Brigham and Women's Hospital | N/A |
| Recruiting | A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine NCT06810505 | AbbVie | Phase 3 |
| Recruiting | Efficacy of Nerve Block Versus Botox in Chronic Migraine Management NCT06684249 | Zagazig University | N/A |
| Completed | Efficacy and Safety of Stellate Ganglion Block With Lidocaine Combined Platelet-rich Plasma to Treat Chronic M NCT06653218 | Beijing Tiantan Hospital | — |
| Recruiting | Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial NCT05337033 | University of Manitoba | Phase 2 |
| Recruiting | A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults NCT06625060 | Ipsen | Phase 2 |
| Not Yet Recruiting | Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Context NCT06428838 | Dr George Medvedev | Phase 3 |
| Recruiting | Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for NCT06603558 | AbbVie | — |
| Recruiting | A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine NCT06554886 | St. Olavs Hospital | N/A |
| Recruiting | The RECLAIM Study. NCT06450444 | Salvia BioElectronics | N/A |
| Not Yet Recruiting | Cannabis for the Prophylactic Treatment of Migraine NCT03972124 | University of Calgary | Phase 2 |
| Recruiting | Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult NCT06322407 | Beijing Tiantan Hospital | N/A |
| Active Not Recruiting | Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine P NCT06414044 | University of Florence | — |
| Recruiting | Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig) NCT06485336 | St. Olavs Hospital | Phase 2 |
| Recruiting | RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment NCT06409832 | University of Florence | — |
| Recruiting | Effectiveness and Tolerability of Eptinezumab NCT06409845 | University of Florence | — |
| Completed | Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse NCT07442916 | IRCCS National Neurological Institute "C. Mondino" Foundation | N/A |
| Recruiting | Repetitive Transcranial Magnetic Stimulation in Treatment and Prophylaxis of Chronic Migraine in Patients With NCT06461767 | Sohag University | N/A |
| Unknown | Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial NCT06170281 | Stanford University | N/A |
| Terminated | A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic Migraine NCT05273151 | Chordate Medical | N/A |
| Terminated | Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects With Chronic NCT05843721 | Chordate Medical | N/A |
| Active Not Recruiting | A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults NCT06047444 | Ipsen | Phase 3 |
| Active Not Recruiting | Brief Interventions in Chronic Migraine NCT05979337 | University of Michigan | N/A |
| Recruiting | Responding With Evidence and Access for Childhood Headaches NCT05889624 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients With Migraine NCT05893914 | Thomas W. Perreault, PT | N/A |
| Completed | Cervical Repositioning Error in Chronic Migraine NCT05933590 | Ahram Canadian University | — |
| Recruiting | Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA NCT05754190 | Brown University | — |
| Recruiting | Gepant treAtments: EffectIveNess and tolERability (GAINER) NCT05903027 | University of Florence | — |
| Completed | Ditan Acute tReatments: Effectiveness and Tolerability (DART) NCT05903040 | University of Florence | — |
| Recruiting | Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments NCT06562400 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Recruiting | Searching for Novel Biological Phenotypes in Migraine Patients Resistant to Treatments NCT06562413 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Recruiting | Biochemical Profiling of Migraine Patients NCT06549270 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Active Not Recruiting | First Evaluation of a Craniofacial Peripheral Nerve Stimulation System in Chronic Migraine NCT05858801 | Salvia BioElectronics | N/A |
| Recruiting | BOTOX® vs. XEOMIN® for Chronic Migraine NCT05598723 | Naval Medical Center Camp Lejeune | Phase 3 |
| Terminated | A Study of Remote Electrical Neuromodulation for Acute Procedural Pain NCT05730556 | Mayo Clinic | N/A |
| Recruiting | Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo) NCT05769348 | University of Michigan | N/A |
| Completed | A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine NCT05679908 | Tonix Pharmaceuticals, Inc. | Phase 2 |
| Completed | The Effect of Different Exercise Types on Migraine Frequency in Individuals With Migraine NCT05568004 | Ege University | N/A |
| Unknown | Monoclonal CGRP Antibodies for Migraine Prevention - a Nationwide Real Life Study NCT05281770 | Austrian Migraine Registry Collaboration | — |
| Unknown | Pilot Study for a Machine Learning Test for Migraine NCT05517200 | Headache Sciences Incorporated | — |
| Unknown | Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia NCT05536050 | Thomas Jefferson University | — |
| Recruiting | Determining the Utility of a Behavioral Intervention in Chronic Migraine NCT05415020 | Mayo Clinic | N/A |
| Unknown | Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment NCT06122545 | Tanta University | N/A |
| Completed | Efficacy of GONB in Patients of Migraine NCT05679765 | Pain Medicine Department | Phase 4 |
| Recruiting | i-NEED: NEw migrainE Drugs Database NCT07103694 | IRCCS San Raffaele Roma | — |
| Completed | Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Diseas NCT05216263 | AbbVie | Phase 3 |
| Recruiting | Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients NCT06309251 | Danone Nutricia SpA Società Benefit | — |
| Unknown | Effectiveness of Multimodal Physical Therapy in Migraine NCT05226559 | Neuromed IRCCS | N/A |
| Recruiting | Laser Acupuncture for Chronic Migraine NCT06219694 | Taichung Veterans General Hospital | N/A |
| Completed | Study to Assess Adverse Events (AEs) When Oral Atogepant Tablet is Given to Adult Chinese Participants Who Com NCT04829747 | Allergan | Phase 3 |
| Completed | Examination of Muscle Stiffness, Tenderness and Pressure Pain Thresholds During a Cycle of Botulinum Toxin A T NCT05328687 | Danish Headache Center | — |
| Completed | Effectiveness of a Health Education Programme for Prevention of Chronic Migraine: A Randomized Clinical Trial NCT04788667 | Universidad de Zaragoza | N/A |
| Unknown | Trip-Tox, Effectiveness of Triptans Before and After Onabotulinumtoxin A Treatment in Chronic Migraine NCT04871152 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Recruiting | Mind Body Balance for Pediatric Migraine NCT04715685 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Epis NCT04686136 | AbbVie | Phase 3 |
| Unknown | Rate , Predictors and Outcome of Chronic Migraine NCT05079659 | Assiut University | — |
| Active Not Recruiting | A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine NCT04616326 | Eli Lilly and Company | Phase 3 |
| Withdrawn | Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache NCT04353505 | Weill Medical College of Cornell University | Phase 1 |
| Recruiting | CGRP Inhibition, Autonomic Function, and Migraine NCT04628429 | Medical University of Vienna | — |
| Unknown | miR-155 Expression in Episodic and Chronic Migraine NCT05891808 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | Biofeedback-VR for Treatment of Chronic Migraine NCT05720819 | University of Washington | N/A |
| Completed | Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action NCT04271202 | Beth Israel Deaconess Medical Center | Phase 4 |
| Completed | A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Epis NCT04437433 | AbbVie | Phase 3 |
| Unknown | Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine NCT04361721 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Unknown | HD-EEG Connectivity Changes in Migraine Patients Undergoing Treatment With Anti-CGRP mAbs NCT06155123 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | Efficacy and Safety of Nerivio Device for Acute Treatment of Migraine in People With Chronic Migraine NCT04194008 | Theranica | N/A |
| Completed | Efficacy and Safety of Nerivio™ for Acute Treatment of Migraine in People With Chronic Migraine NCT04161807 | Theranica | N/A |
| Terminated | Saline Injections for Prophylactic Treatment of Chronic Migraine NCT03919045 | Göteborg University | Phase 4 |
| Completed | Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine NCT03855137 | Allergan | Phase 3 |
| Completed | Mindfulness Therapy for Chronic Migraine NCT03671681 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | Phase 4 |
| Unknown | Osteopathic Manipulative Treatment and Migraine Headaches NCT04976985 | St. Luke's Hospital, Pennsylvania | N/A |
| Recruiting | Study on 30 Outpatients with Chronic Migraine Treated with Well-Being Therapy or with a Control Therapy NCT03404336 | University of Florence | N/A |
| Completed | Tertiary Care With or Without Manual Therapy for Chronic Migraine NCT03395457 | Bournemouth University | N/A |
| Unknown | rTMS for the Prevention Treatment of CM: a Single Arm Study NCT03568617 | Peking Union Medical College Hospital | N/A |
| Withdrawn | Treatment of Cervical Pain in Chronic Migraine NCT03453203 | University Hospitals Cleveland Medical Center | N/A |
| Completed | Study to Evaluate the Efficacy of Intranasal Kinetic Oscillation Stimulation in the Preventive Treatment of Ch NCT03400059 | Chordate Medical | N/A |
| Completed | Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients NCT04324710 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | Introvision for Migraine and Headaches NCT03507400 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Comparison Between Transcranial Stimulation Protocols With Continuous Current in the Chronic Migraine NCT03414203 | Federal University of Paraíba | N/A |
| Completed | Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine NCT03108469 | Smith, Timothy R., M.D. | Phase 2 |
| Unknown | GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study NCT02686983 | Jakob Møller Hansen, MD. | Phase 4 |
| Completed | Neurologic Signatures of Chronic Pain Disorders NCT02747940 | Taipei Veterans General Hospital, Taiwan | Phase 4 |
| Completed | Evaluation of Galcanezumab in the Prevention of Chronic Migraine NCT02614261 | Eli Lilly and Company | Phase 3 |
| Completed | Biobehavioral Physical Therapy Strategies Based on Therapeutic Exercise Applied to Chronic Migraine Patients NCT02514148 | Universidad Autonoma de Madrid | N/A |
| Completed | Effect of Treatment of Temporomandibular Joint in Patients With Chronic Migraine and Temporomandibular Disorde NCT02627014 | Cardenal Herrera University | N/A |
| Completed | Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging C NCT02436499 | University of Manitoba | Phase 4 |
| Completed | Physiological Changes With SPG Stimulation in Migraine Patients NCT02510742 | Danish Headache Center | N/A |
| Completed | Anodal tDCS in Chronic Migraine With Medication Overuse NCT04336267 | IRCCS National Neurological Institute "C. Mondino" Foundation | N/A |
| Recruiting | Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics NCT03231241 | Stanford University | — |
| Unknown | Occipital Transcutaneous Stimulation in Chronic Migraine NCT02307071 | University of Liege | Phase 4 |
| Unknown | A Study to Evaluate Botulinum Toxin Type A for Injection（HengLi®）for Prophylactic Treatment of Chronic Migrain NCT02291380 | Lanzhou Institute of Biological Products Co., Ltd | Phase 3 |
| Completed | Anesthetic Blockades and Migraine NCT02188394 | César Fernández-de-las-Peñas | Phase 2 |
| Completed | Hypothalamus Connectivity in Chronic and Episodic Migraine NCT02328976 | University Hospital, Toulouse | N/A |
| Completed | Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine NCT02037425 | Cady, Roger, M.D. | Phase 4 |
| Completed | Assessment of LBR-101 In Chronic Migraine NCT02021773 | Teva Branded Pharmaceutical Products R&D, Inc. | Phase 2 |
| Withdrawn | RCT Versus Placebo of rTMSQP Over Visual Cortex for the Prevention of Chronic Migraine NCT02122744 | University of Liege | N/A |
| Completed | Cathodal tDCS in Chronic Migraine: Neurophysiological Study and Pilot Therapeutic Trial NCT02122237 | University of Liege | Phase 3 |
| Completed | A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines NCT01813591 | Dent Neuroscience Research Center | Phase 2 |
| Completed | Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BO NCT01833130 | Allergan | Phase 4 |
| Completed | Impact of a Nurse for Migraine Management: the IMPACT Project NCT01804517 | Notre-Dame Hospital, Montreal, Quebec, Canada | — |
| Unknown | Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse Heada NCT01752439 | Dr Armando Perrotta, MD, PhD | N/A |
| Completed | A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Effi NCT01700387 | Cady, Roger, M.D. | Phase 4 |
| Completed | Non-Invasive Neurostimulation for the Prevention of Chronic Migraine NCT01667250 | ElectroCore INC | N/A |
| Completed | Use of the Tx360 Nasal Applicator in the Treatment of Chronic Migraine NCT01709708 | Tian Medical Inc. | Phase 4 |
| Unknown | Investigation of the Blood-brain and Blood-dura Barrier Durin Migraine Attacks Using MRI NCT02202486 | Glostrup University Hospital, Copenhagen | — |
| Completed | Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis NCT02639598 | Taipei Veterans General Hospital, Taiwan | Phase 4 |
| Completed | Migraine and Body Composition NCT01720862 | Johns Hopkins University | — |
| Unknown | Study of MIGRA-ZEN RELIEF PLUS In the Treatment of Chronic Migraine Headache NCT01135784 | RZN Nutraceuticals, Inc. | Phase 2 |
| Completed | Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Im NCT01741246 | University of California, San Francisco | — |
| Completed | Smell Sensitivity in Chronic Migraine: A Case-Control Study NCT01687088 | Thomas Jefferson University | — |
| Completed | Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic Migraine NCT01393522 | Timothy Smith | N/A |
| Unknown | Preventive Treatment of Episodic and Chronic Migraine NCT01319825 | California Medical Clinic for Headache | Phase 4 |
| Completed | Efficacy of Behavioral Insomnia Treatment for Chronic Migraine NCT01314651 | Daniel Riche | N/A |
| Withdrawn | Aspirin Resistance in Women With Migraine NCT01257893 | Swedish Medical Center | N/A |
| Completed | Treximet in the Treatment of Chronic Migraine NCT01090050 | Cady, Roger, M.D. | Phase 4 |
| Terminated | Efficacy and Safety of Cyclobenzaprine Hydrochloride Extended Release for the Treatment of Chronic Migraine NCT01151787 | Kennedy Medical Group | Phase 3 |
| Completed | Calcitonin Gene-related Peptide Levels in Chronic Migraine NCT01071096 | Cady, Roger, M.D. | Phase 4 |
| Completed | Candesartan Versus Propranolol for Migraine Prevention NCT00884663 | Norwegian University of Science and Technology | Phase 2 / Phase 3 |
| Completed | Double-blind Randomized Clinical Trial of Transcranial Magnetic Stimulation in Chronic Migraine NCT01496950 | Hospital Israelita Albert Einstein | Phase 1 |
| Completed | NINDS CRC Chronic Migraine Treatment Trial NCT00772031 | Anne Lindblad | Phase 3 |
| Completed | OnabotulinumtoxinA Injections in Chronic Migraine, Targeted to Sites of Pericranial Myofascial Pain NCT03175263 | University Hospital, Limoges | — |