| Not Yet Recruiting | B7-H3.CD28Z.CART in CNS Neoplasms NCT07390539 | Robbie Majzner | Phase 1 |
| Recruiting | Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712 | Jeffrey N. Bruce | Phase 1 |
| Recruiting | A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without NCT06496971 | NaviFUS Corporation | Phase 3 |
| Completed | Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent NCT06322342 | Reveal Pharmaceuticals Inc. | Phase 2 |
| Not Yet Recruiting | Azoles Targeting Recurrent High Grade Gliomas NCT03763396 | University Health Network, Toronto | EARLY_Phase 1 |
| Completed | Performance of Elucirem in DSC-MRI Perfusion of Brain Gliomas NCT06057168 | Guerbet | Phase 3 |
| Active Not Recruiting | Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT) NCT05634707 | Duke University | EARLY_Phase 1 |
| Recruiting | ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids NCT05629702 | University of Birmingham | Phase 2 |
| Terminated | RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant NCT04525014 | EpicentRx, Inc. | Phase 1 |
| Withdrawn | Multimodality MRI and Liquid Biopsy in GBM NCT04776980 | Abramson Cancer Center at Penn Medicine | EARLY_Phase 1 |
| Completed | Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM NCT04988750 | NaviFUS Corporation | N/A |
| Recruiting | Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles) NCT04427384 | GT Medical Technologies, Inc. | — |
| Terminated | Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6 NCT04074785 | University of Texas Southwestern Medical Center | EARLY_Phase 1 |
| Completed | Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescen NCT04023669 | St. Jude Children's Research Hospital | Phase 1 |
| Terminated | Neurosurgical Transitional Care Programme NCT03593330 | Barts & The London NHS Trust | N/A |
| Completed | Vegetative Monitoring During Brainstem-associated Surgery NCT03666507 | University Hospital Tuebingen | — |
| Completed | Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brai NCT02905110 | The University of Texas Health Science Center, Houston | EARLY_Phase 1 |
| Completed | Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Ependym NCT02940483 | The University of Texas Health Science Center, Houston | EARLY_Phase 1 |
| Recruiting | Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Re NCT02800486 | Northwell Health | Phase 2 |
| Active Not Recruiting | T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors NCT02442297 | Baylor College of Medicine | Phase 1 |
| Completed | Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors NCT02644460 | Emory University | Phase 1 |
| Withdrawn | More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery NCT01445691 | Constantinos Hadjipanayis | Phase 2 |
| Completed | Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumo NCT02458339 | The University of Texas Health Science Center, Houston | Phase 1 |
| Terminated | Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas NCT01966809 | Harry T Whelan, MD | Phase 2 |
| Completed | Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramo NCT03262636 | University of Pennsylvania | Phase 1 |
| Completed | D2C7 for Adult Patients With Recurrent Malignant Glioma NCT02303678 | Darell Bigner | Phase 1 |
| Completed | Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas NCT02238496 | Andrew B Lassman, MD | Phase 1 |
| Completed | ANG1005 in Patients With Recurrent High-Grade Glioma NCT01967810 | Angiochem Inc | Phase 2 |
| Completed | Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors NCT01682746 | Harry T Whelan, MD | Phase 1 |
| Completed | Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent G NCT01520870 | Grupo Español de Investigación en Neurooncología | Phase 2 |
| Completed | Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors NCT00747253 | Monteris Medical | Phase 1 |
| Completed | Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Glioma NCT00575887 | Marmara University | Phase 2 |
| Completed | A Phase I/II Study of the Photon Radiosurgery System NCT00179907 | Ann & Robert H Lurie Children's Hospital of Chicago | Phase 1 / Phase 2 |
| Completed | Study of High-Dose Chemotherapy With Bone Marrow or Stem Cell Transplant for Rare Poor-Prognosis Cancers NCT00141765 | University of Michigan Rogel Cancer Center | Phase 2 |