| Recruiting | Alendronate for Osteonecrosis in Adults With Sickle Cell Disease NCT06016634 | University of California, Davis | Phase 2 |
| Not Yet Recruiting | Effect of HBOT on Femoral Head Avascular Necrosis (AVN) NCT06931301 | Yale University | N/A |
| Active Not Recruiting | Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With NCT07391592 | MicroPort Orthopedics Inc. | — |
| Active Not Recruiting | A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary H NCT06564636 | Smith & Nephew, Inc. | — |
| Terminated | MDR - Longevity IT Oblique and Offset Liners NCT05980234 | Zimmer Biomet | — |
| Active Not Recruiting | Cemented vs Cementless Persona Keel RCT NCT05630053 | Zimmer Biomet | N/A |
| Recruiting | Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty) NCT05787821 | Zimmer Biomet | — |
| Enrolling By Invitation | G7 Freedom Constrained Vivacit-E Liners NCT05587244 | Zimmer Biomet | N/A |
| Enrolling By Invitation | G7 Dual Mobility With Vivacit-E or Longevity PMCF NCT05548972 | Zimmer Biomet | N/A |
| Completed | Proximal Humerus Fracture Dislocation Direction and Avascular Necrosis NCT05735561 | Fraser Orthopaedic Research Society | — |
| Active Not Recruiting | The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head NCT05706909 | The Cleveland Clinic | — |
| Enrolling By Invitation | Tornier HRS (Humeral Reconstruction System) Study (REVIVE) NCT05500066 | Stryker Trauma and Extremities | — |
| Recruiting | Hydrogel Coating to Reduce Post-surgical Infection After Joint Arthroplasty NCT05679232 | Medacta International SA | N/A |
| Active Not Recruiting | Sickle Cell Disease (SCD) Bone Pain Study NCT05283148 | University of California, Davis | N/A |
| Not Yet Recruiting | S-11 SMR TT Hybrid Glenoid and Cementless Finned Short Stem NCT05314387 | Limacorporate S.p.a | — |
| Recruiting | Clinical and Radiological Outcomes of Medacta Shoulder System FR NCT05926622 | Medacta International SA | — |
| Terminated | Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (U NCT04797897 | Smith & Nephew, Inc. | N/A |
| Active Not Recruiting | Insignia™ Hip Stem Outcomes Study NCT05144191 | Stryker Orthopaedics | N/A |
| Active Not Recruiting | TESS V3 Modular Total Shoulder System PMCF NCT05002959 | Zimmer Biomet | — |
| Enrolling By Invitation | Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With NCT04816773 | MicroPort Orthopedics Inc. | — |
| Completed | Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA NCT04910048 | University of Arkansas | N/A |
| Active Not Recruiting | Pyrocarbon Clinical Follow-up Study NCT05049993 | Stryker Trauma and Extremities | — |
| Recruiting | Perform Humeral System Study NCT05067543 | Stryker Trauma and Extremities | — |
| Active Not Recruiting | Persona Ti-Nidium Post-Market Clinical Follow-up NCT04817969 | Zimmer Biomet | N/A |
| Active Not Recruiting | Clinical and Radiological Outcomes of Medacta Shoulder System (BE) NCT05002335 | Medacta International SA | — |
| Active Not Recruiting | Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur NCT04301622 | MicroPort Orthopedics Inc. | — |
| Active Not Recruiting | The Medacta International GMK Sphere Cementless Post-Marketing Surveillance Study NCT05003414 | Medacta International SA | — |
| Active Not Recruiting | Prospective Study for the Evaluation of the Cementless Anatomic Femoral Stem Minimax -Launay NCT06012656 | Medacta International SA | — |
| Active Not Recruiting | Clinical and Radiological Outcomes of Medacta Shoulder System NCT03547947 | Medacta International SA | — |
| Enrolling By Invitation | Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ) NCT03040778 | University of Washington | Phase 3 |
| Active Not Recruiting | G7 BiSpherical Acetabular Shell PMCF Study NCT03266874 | Zimmer Biomet | — |
| Active Not Recruiting | Anatomical Shoulder Domelock System Study NCT03312465 | Zimmer Biomet | — |
| Completed | Femoral Neck Fracture in Adult and Avascular Necrosis and Nonunion NCT03666637 | Security Forces Hospital | — |
| Unknown | AL-2 MP-1 (Polyimide) Acetabular Liner NCT02503891 | M.M.A Tech Ltd. | N/A |
| Completed | Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty. NCT03409666 | Zimmer Biomet | N/A |
| Recruiting | Physica System Total Knee Replacement Registry Study NCT03048201 | Limacorporate S.p.a | N/A |
| Terminated | Clinical Evaluation of the TITAN™ Total Shoulder System NCT03245320 | Smith & Nephew, Inc. | — |
| Active Not Recruiting | Persona Partial Knee Clinical Outcomes Study NCT03034811 | Zimmer Biomet | N/A |
| Completed | Opioid-Free Shoulder Arthroplasty NCT03540030 | OrthoCarolina Research Institute, Inc. | Phase 4 |
| Completed | Aequalis Pyrocarbon IDE; Replacing the Humeral Head in Hemi-Arthroplasty NCT02525783 | Stryker Trauma and Extremities | — |
| Active Not Recruiting | BC Study of G7 Cup and Compatible Femoral Stems NCT03456622 | Zimmer Biomet | — |
| Completed | A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in China NCT02399007 | Johnson & Johnson Medical (Suzhou) Ltd. | N/A |
| Completed | Project JAY THA Registration Study NCT02347384 | Smith & Nephew Orthopaedics (Beijing) Limited | N/A |
| Terminated | PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip Ar NCT03672370 | Zimmer Biomet | — |
| Withdrawn | Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty: NCT02342977 | Indiana University School of Medicine | Phase 2 |
| Completed | Cementless Oxford Partial Knee Controlled Observational Study NCT02350049 | Zimmer Biomet | — |
| Terminated | Signature Acetabular Posterior/Lateral Data Collection NCT02220478 | Zimmer Biomet | N/A |
| Completed | Clinical and Radiographic Outcomes of the Corin Tri-Fit Total Hip Replacement NCT02162186 | Corin | — |
| Completed | TC-A Registration Study NCT02139345 | Smith & Nephew Medical (Shanghai) Ltd | N/A |
| Completed | Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS) NCT02096211 | DePuy Orthopaedics | N/A |
| Completed | iAssist vs. Conventional Instrumentation in Total Knee Arthroplasty NCT03111407 | Zimmer, GmbH | N/A |
| Completed | CT Imaging Evaluation of Humerus Fractures NCT02170545 | Virginia Commonwealth University | — |
| Completed | Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head NCT02096198 | DePuy Orthopaedics | — |
| Active Not Recruiting | Comprehensive Nano - Post Market Clinical Follow-Up Study NCT03423953 | Zimmer Biomet | — |
| Terminated | A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup NCT02196818 | Medacta International SA | — |
| Completed | Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral Densi NCT02087436 | Zimmer Biomet | N/A |
| Terminated | Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient Population NCT02087449 | Zimmer Biomet | — |
| Completed | Arcos Revision Stem: Evaluation of Clinical Performance NCT01820611 | Zimmer Biomet | — |
| Active Not Recruiting | PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip Arthroplasty NCT03372278 | Zimmer Biomet | — |
| Unknown | Trinity™ BIOLOX Delta™ CoC THR Multi-center Study NCT01921309 | Corin | N/A |
| Unknown | Direct Anterior Versus Posterior Total Hip Arthroplasty Surgical Approaches NCT01807494 | New Lexington Clinic | N/A |
| Active Not Recruiting | The Medacta International GMK Sphere Post-Marketing Surveillance Study NCT02199600 | Medacta International SA | N/A |
| Active Not Recruiting | Sidus(TM) Post Market Clinical Follow-up (PMCF) Study NCT01700543 | Zimmer Biomet | — |
| Terminated | Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacemen NCT01635166 | DePuy International | Phase 4 |
| Completed | A Clinical Evaluation of Metal Ion Release From Metal-on-Metal Cementless Total Hip Arthroplasty NCT00757354 | Zimmer Biomet | N/A |
| Terminated | 28mm Ceramic-on-Ceramic Total Hip Replacement Study NCT01657435 | DePuy Orthopaedics | — |
| Completed | Metal Ions in Ceramic on Metal Total Hip Arthroplasty NCT01437124 | Hussain Kazi | — |
| Completed | Allofit® IT With HXPE in Total Hip Arthroplasty NCT03672929 | Zimmer Biomet | — |
| Active Not Recruiting | Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study NCT01307384 | Zimmer Biomet | — |
| Active Not Recruiting | Database Retrieval for the Comprehensive Shoulder NCT03409718 | Zimmer Biomet | — |
| Completed | Continuum™ Metal Bearing System in Total Hip Arthroplasty NCT03382652 | Zimmer Biomet | — |
| Terminated | PMCF Study of the CLS Brevius Stem With Kinectiv Technology NCT03410940 | Zimmer Biomet | — |
| Terminated | Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder Arthroplasty NCT01480453 | Zimmer Biomet | — |
| Completed | Acetabular Shell Positioning Using Patient Specific Instruments NCT01791738 | The Cleveland Clinic | Phase 1 |
| Active Not Recruiting | Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System NCT01480440 | Zimmer Biomet | — |
| Completed | Multi Centre Study on TESS V2 Shoulder System NCT03431857 | Zimmer Biomet | — |
| Active Not Recruiting | Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up Study NCT03343171 | Zimmer Biomet | — |
| Completed | Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anteri NCT01285843 | Medacta International SA | N/A |
| Terminated | An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Tota NCT01134445 | DePuy International | Phase 4 |
| Terminated | Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction NCT03382665 | Zimmer Biomet | — |
| Active Not Recruiting | AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study NCT01107340 | Medacta International SA | N/A |
| Completed | A Study on M2a Magnum Total Hip Arthroplasty NCT01010763 | Zimmer Biomet | N/A |
| Terminated | Trilogy AB Acetabular Hip System Post Approval Study NCT00715026 | Zimmer Biomet | Phase 4 |
| Completed | A Comparison of Two Different Surgical Techniques for Total Hip Resurfacing NCT00750984 | Zimmer Biomet | N/A |
| Completed | Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects NCT00721994 | Corin | — |
| Completed | Cormet Post-PMA Study: New Enrollment NCT00722007 | Corin | N/A |
| Completed | Fitmore Hip Stem PMCF Study: A Multi-centre, Non-comparative, Prospective Post-market Clinical Follow-up Study NCT03411044 | Zimmer Biomet | — |
| Terminated | Efficacy of the CLP® Hip - Retrospective NCT00764842 | Encore Medical, L.P. | — |
| Terminated | Retrospective Study of the Linear™ Hip NCT00764959 | Encore Medical, L.P. | — |
| Unknown | Comparison of Hip Resurfacing to Large Femoral Head Total Hip Arthroplasty NCT00175487 | University of British Columbia | N/A |
| Withdrawn | A Clinical Investigation of the Comprehensive®, BioModular®, and Bi-Angular® Shoulder Systems NCT00699270 | Biomet Orthopedics, LLC | — |
| Completed | Anthology Hip Replacement System - Orthopaedic Data Evolution Panel (ODEP) Surveillance Study NCT04425603 | Smith & Nephew Orthopaedics AG | — |
| Terminated | A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Beari NCT00872222 | DePuy International | Phase 4 |
| Terminated | Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem NCT01422564 | Nova Scotia Health Authority | Phase 4 |
| Completed | The 3DKnee™ System: A Post-Market Study NCT00764673 | Encore Medical, L.P. | Phase 4 |
| Terminated | Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Tot NCT00872547 | DePuy International | Phase 4 |
| Terminated | A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip NCT00872573 | DePuy International | Phase 4 |
| Terminated | A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic- NCT00873444 | DePuy International | Phase 4 |
| Terminated | Avascular Necrosis (AVN) Long-Term Follow-up NCT00833430 | Zimmer Biomet | — |
| Completed | A Clinical Investigation of the C2a-Taper™ Acetabular System NCT00578851 | Biomet Orthopedics, LLC | — |
| Completed | A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System NCT00578994 | Biomet Orthopedics, LLC | — |
| Completed | A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hi NCT00872066 | DePuy International | Phase 4 |
| Completed | A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement NCT00698152 | Zimmer Biomet | — |
| Terminated | Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System NCT00546598 | DePuy Orthopaedics | Phase 4 |
| Completed | A Clinical Investigation of the Taperloc® Microplasty™ Hip System NCT00699309 | Biomet Orthopedics, LLC | — |
| Terminated | A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replac NCT00208455 | DePuy International | Phase 4 |
| Completed | A Clinical Investigation of the Balance® Microplasty™ Hip System NCT00699088 | Biomet Orthopedics, LLC | — |
| Completed | A Prospective Clinical Study On A Total Hip Resurfacing System NCT00604734 | Zimmer Biomet | N/A |
| Completed | A Prospective Clinical Study On A Total Hip Resurfacing System NCT00603395 | St. Anna Ziekenhuis, Geldrop, Netherlands | N/A |
| Withdrawn | A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bea NCT00208429 | DePuy International | Phase 4 |
| Terminated | A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in P NCT00208364 | DePuy International | Phase 4 |
| Terminated | A Clinical Investigation of the Copeland™ Humeral Resurfacing Head NCT00698750 | Biomet Orthopedics, LLC | — |
| Terminated | Cormet Large Diameter Metal on Metal (LDMOM) Total Hip System (G030265) NCT00867256 | Corin | N/A |
| Completed | Cementless Alumina-Alumina Total Hip and Hybrid NCT00764530 | Encore Medical, L.P. | N/A |
| Terminated | A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing NCT00872794 | DePuy International | Phase 4 |
| Terminated | A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing S NCT00208377 | DePuy International | Phase 4 |
| Terminated | A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement NCT00208390 | DePuy International | Phase 4 |
| Terminated | Clinical Study Comparing Two Implant Surface Finishes in Patients Undergoing Cementless Total Hip Replacement NCT00306917 | DePuy Orthopaedics | N/A |
| Terminated | Atorvastatin to Prevent Avascular Necrosis of Bone in Steroid Treated Exacerbated Systemic Lupus Erythematosus NCT00412841 | NYU Langone Health | Phase 2 |
| Terminated | A Randomised Single Centre Study to Compare the Long-term Performance of Acryloc™ and Palacos® R Bone Cements NCT00208403 | DePuy International | Phase 4 |
| Completed | A Clinical Investigation of the Discovery™ Elbow System NCT00698867 | Biomet Orthopedics, LLC | — |
| Terminated | A Clinical Investigation of the M2a- 38™ Hip System NCT00698503 | Biomet Orthopedics, LLC | — |
| Terminated | A Clinical Investigation of the M2a- Taper™ Hip System NCT00698633 | Biomet Orthopedics, LLC | — |
| Completed | AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or Prednison NCT00719147 | St. Jude Children's Research Hospital | — |
| Completed | A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polye NCT00208442 | DePuy International | Phase 4 |
| Completed | Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA NCT00289107 | DePuy Orthopaedics | N/A |
| Completed | Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement NCT00306930 | DePuy Orthopaedics | N/A |
| Terminated | A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in NCT00208468 | DePuy International | Phase 3 |
| Completed | Mobile - Bearing Knee Study NCT00765362 | Encore Medical, L.P. | Phase 3 |
| Completed | Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data NCT03573765 | University of Oxford | — |
| Terminated | A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem NCT00208351 | DePuy International | Phase 3 |