| Not Yet Recruiting | SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study NCT07468305 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy NCT07461220 | Integrative Research Laboratories AB | Phase 1 / Phase 2 |
| Not Yet Recruiting | Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel) NCT07404410 | Giovanna Zamboni | N/A |
| Recruiting | Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia NCT07279740 | Sunnybrook Health Sciences Centre | Phase 2 |
| Recruiting | Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders NCT07237009 | KompanionCare SAS | — |
| Recruiting | Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics NCT05877885 | AdventHealth | N/A |
| Not Yet Recruiting | VC/VS for Apathy in PD NCT06991335 | Nora Vanegas | N/A |
| Recruiting | A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults NCT06919094 | Montefiore Medical Center | N/A |
| Recruiting | Accelerated rTMS vs. Sham for Stroke Apathy NCT07113067 | Medical University of South Carolina | Phase 1 / Phase 2 |
| Recruiting | Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease NCT07118956 | Anhui Medical University | N/A |
| Not Yet Recruiting | Effort and Antidepressant Study Test NCT06696482 | University of Oxford | Phase 1 / Phase 2 |
| Enrolling By Invitation | A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneo NCT06642454 | Anhui Medical University | N/A |
| Completed | Phase I Trial Evaluating the Pharmacokinetics of Single Ascending Oral Doses of IRL757 in Healthy Elderly Volu NCT06699628 | Integrative Research Laboratories AB | Phase 1 |
| Recruiting | Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept NCT06914284 | Hospital Center Guillaume Régnier | — |
| Recruiting | Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms. NCT06482554 | Louisiana State University Health Sciences Center Shreveport | Phase 3 |
| Not Yet Recruiting | Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation NCT06184165 | University Hospital, Strasbourg, France | N/A |
| Not Yet Recruiting | Methylphenidate for Apathy in Veterans With Parkinson's Disease NCT05669170 | Ralph H. Johnson VA Medical Center | Phase 2 |
| Completed | Accelerated rTMS for Post-Stroke Apathy NCT05878457 | Medical University of South Carolina | Phase 1 |
| Completed | Cognitive Stimulation Therapy NCT05808530 | Hasan Kalyoncu University | N/A |
| Completed | Lifestyle Intervention for Improving Insulin Resistance and Concern for Health NCT05649176 | Pennington Biomedical Research Center | N/A |
| Recruiting | Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression NCT07146503 | Riccardo Guglielmo | — |
| Terminated | Effect of Istradefylline Treatment on Behavioral Measures of Apathy in Parkinson's Disease. NCT05182151 | Medical University of South Carolina | — |
| Active Not Recruiting | Effects of t-DCS and Cognitive Training on Apathy in Elderly With Minor Neurocognitive Impairment NCT05232877 | Centre Hospitalier Universitaire de Nice | N/A |
| Unknown | Study of the Effectiveness of Mental Contrasting and Implementation Intention in the Management of Apathy in S NCT04781179 | University Hospital, Montpellier | N/A |
| Recruiting | Targeting Apathy With Music in Parkinson's Disease NCT05505019 | University of British Columbia | N/A |
| Recruiting | Multidimensional Apathy in Psychiatric Pathologies. NCT04757220 | University Hospital, Strasbourg, France | N/A |
| Unknown | Non-disabling Ischemic Cerebrovascular Event With Apathy NCT04917237 | Changhai Hospital | — |
| Unknown | In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy. NCT03998852 | University Hospital, Bordeaux | Phase 3 |
| Completed | The Effects of Apathy on Different Forms of Fatigue NCT04573712 | Centre Hospitalier Universitaire de Nice | N/A |
| Unknown | Motive-specific Intervention for Negative Symptoms in Schizophrenia NCT04793438 | University of Zurich | N/A |
| Completed | Move to Improve Physical Activity in Parkinson's Disease NCT04051151 | University of Pennsylvania | N/A |
| Completed | Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment NCT03590327 | VA Office of Research and Development | N/A |
| Unknown | Dementia Associated Apathy. NCT03293537 | Zurich University of Applied Sciences | N/A |
| Completed | Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System NCT03272230 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Motivation and Methylphenidate NCT03190681 | Institut National de la Santé Et de la Recherche Médicale, France | EARLY_Phase 1 |
| Completed | Evolution of Hypodopaminergic Syndrome in Early Parkinson's Disease NCT03141944 | University Hospital, Grenoble | — |
| Terminated | Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy NCT02915484 | Stony Brook University | N/A |
| Completed | Apathy in Tourette Syndrome and Changes in Quality of Life NCT02765178 | University of Florida | — |
| Completed | Apathy in Dementia Methylphenidate Trial 2 NCT02346201 | Johns Hopkins Bloomberg School of Public Health | Phase 3 |
| Completed | Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrat NCT02496312 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | Repetitive Transcranial Magnetic Stimulation for Apathy in Alzheimer's Dementia NCT02190084 | Central Arkansas Veterans Healthcare System | Phase 4 |
| Unknown | Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study NCT02190019 | Central Arkansas Veterans Healthcare System | Phase 4 |
| Unknown | Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi- NCT01765257 | University Hospital, Clermont-Ferrand | Phase 4 |
| Unknown | Repetitive Transcranial Magnetic Stimulation for Apathy Treatment in Alzheimer's Disease NCT01885806 | Federal University of Minas Gerais | Phase 2 |
| Completed | Role of Mesocorticolimbic Pathway in Apathy of Patients With Parkinson's Disease. - Study Using Diffusion Tens NCT01794195 | University Hospital, Clermont-Ferrand | N/A |
| Terminated | Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia. NCT01825577 | St. Louis University | Phase 4 |
| Completed | Apathy in Schizophrenia NCT01689181 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Unknown | Non Motors Aspects in De Novo Parkinson's Disease NCT02786667 | University Hospital, Grenoble | Phase 3 |
| Completed | Apathy Cure Through Bupropion in Huntington's Disease NCT01914965 | Charite University, Berlin, Germany | Phase 2 |
| Completed | Effects of Transcranial Direct Current Stimulation on the Apathy of Alzheimer's Disease NCT01481558 | University of Sao Paulo | Phase 2 |
| Completed | Apathy in Dementia Methylphenidate Trial (ADMET) NCT01117181 | Johns Hopkins Bloomberg School of Public Health | Phase 2 |
| Completed | The Role of Apathy in Glycemic Control NCT00844090 | US Department of Veterans Affairs | N/A |
| Completed | Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia NCT00767091 | University Hospital, Lille | Phase 3 |
| Withdrawn | Improving Function, Quality of Life, Glycemia in Diabetics With Dementia NCT00792662 | University of Nebraska | Phase 4 |
| Completed | Role of Apathy in the Effectiveness of Weight Loss Interventions NCT00548652 | VA Nebraska Western Iowa Health Care System | N/A |
| Completed | Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study NCT00495820 | VA Office of Research and Development | Phase 4 |
| Completed | Treatment of Apathy in Alzheimer's Disease With Modafinil NCT01172145 | Brown University | Phase 3 |
| Completed | Wellbutrin XL Effects on SSRIs Induced Changes NCT00456820 | Indiana University School of Medicine | Phase 4 |