| Enrolling By Invitation | Quadriceps and Hamstring Activation Timing NCT07532980 | KTO Karatay University | — |
| Recruiting | Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells NCT06798623 | The Methodist Hospital Research Institute | Phase 1 |
| Recruiting | ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws NCT06357091 | Alexander Rofner-Moretti | N/A |
| Not Yet Recruiting | Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair NCT07318272 | Gazi University | — |
| Not Yet Recruiting | Proprioceptive Training for Gait and Knee Function After Anterior Cruciate Ligament Reconstruction NCT07268651 | Universiti Sains Malaysia | N/A |
| Not Yet Recruiting | Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction NCT07217613 | NYU Langone Health | N/A |
| Recruiting | Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction NCT07243535 | Egas Moniz - Cooperativa de Ensino Superior, CRL | N/A |
| Not Yet Recruiting | BFR Training for Post ACLR NCT07142889 | Udayana University | N/A |
| Recruiting | Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery NCT07020312 | Rush University Medical Center | Phase 2 |
| Recruiting | Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees NCT06590402 | Hospital for Special Surgery, New York | Phase 4 |
| Recruiting | Tourniquet vs. Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction NCT06819696 | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | N/A |
| Completed | Short-Term Effects of Trigger Point Dry Needling on Neuromuscular Control in Individuals Following Anterior Cr NCT07039240 | Universidad Rey Juan Carlos | N/A |
| Completed | Neuromuscular Effects of Spinal Manipulation in Individuals Following Anterior Cruciate Ligament Reconstructio NCT07032623 | Universidad Rey Juan Carlos | N/A |
| Recruiting | Effects of Eccentric Training in the Rehabilitation of Patients Undergoing Anterior Cruciate Ligament Reconstr NCT06905691 | Federal University of Health Science of Porto Alegre | N/A |
| Recruiting | Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility St NCT06858293 | Marquette University | N/A |
| Recruiting | Proprioception, Muscle Strength and Kinesiophobia After Anterior Cruciate Ligament Reconstruction NCT06538792 | Bezmialem Vakif University | — |
| Not Yet Recruiting | Operation ACL: Rehabilitation After Anterior Cruciate Ligament Reconstruction NCT06318039 | Linnaeus University | N/A |
| Enrolling By Invitation | Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study NCT06892899 | May Arna Risberg | — |
| Recruiting | The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruct NCT06493851 | Assaf-Harofeh Medical Center | N/A |
| Enrolling By Invitation | Blood Flow Restriction Following ACLR w/Quad Autograft NCT06636045 | University of Kansas Medical Center | — |
| Completed | Effect of Different Focused Techniques on Thigh Muscle Activation After Anterior Cruciate Ligament Reconstruct NCT05342415 | Hacettepe University | N/A |
| Enrolling By Invitation | Incrediwear ACL MCL Arthroscopic Surgery Recovery Study NCT06240780 | Oklahoma Joint Reconstruction Institute | N/A |
| Recruiting | Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstructio NCT06341192 | Chang Gung Memorial Hospital | N/A |
| Recruiting | To Investigate the Effect of PEMF for Pateitns After Anterior Cruciate Ligament Reconstruction With Hamstring NCT06464705 | Chinese University of Hong Kong | N/A |
| Completed | Quantifying Patellar Tendon Microstructure Using DTI NCT06381492 | University of Wisconsin, Madison | — |
| Completed | Femoral Triangle Block Versus Adductor Canal Block in Arthroscopic Anterior Cruciate Ligament Reconstruction NCT06402110 | Tanta University | N/A |
| Recruiting | Neuromuscular Electrical Stimulation Superimposed or Not on Voluntary Contraction After Reconstruction of the NCT06259968 | Federal University of Health Science of Porto Alegre | N/A |
| Recruiting | Graft Maturity After Blood Flow Restriction Training in ACL Reconstruction NCT05972876 | Zuyderland Medisch Centrum | N/A |
| Completed | Comparison of the Efficacy of Telerehabilitation and In-person Rehabilitation Based on Wearable Devices After NCT06327555 | Peking University Third Hospital | N/A |
| Not Yet Recruiting | Tele-rehabilitation After Anterior Cruciate Ligament Reconstruction NCT06232824 | Kexin Wang, MM | N/A |
| Completed | Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults NCT06233825 | Dr. Chris McGlory, PhD | N/A |
| Unknown | Knee Care @Home Programme Feasibility Trial NCT06152380 | University of Évora | — |
| Unknown | The Knee Care @Home Programme Following Anterior Ligament Reconstruction NCT05828355 | University of Évora | N/A |
| Unknown | High Intensity Resistance Training With and Without Blood Flow Restriction in ACL Reconstruction NCT06131047 | Riphah International University | N/A |
| Recruiting | Exploring Prolonged AMR in ACL Reconstructed Patients NCT06430775 | University Ghent | — |
| Recruiting | The Effects of Cognitive Dual-Tasking in Later Stages of Rehabilitation After ACL Reconstruction NCT06206200 | University Ghent | N/A |
| Active Not Recruiting | Predictors of Anterior Patellofemoral Pain After Anterior Cruciate Ligament Reconstruction NCT06185803 | GCS Ramsay Santé pour l'Enseignement et la Recherche | — |
| Recruiting | Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstru NCT05012982 | Yale University | N/A |
| Unknown | Comparison of Kinematic Movements Between ACL Deficiency With ACL Reconstruction and Healthy People NCT05619393 | Wang Joon Ho | N/A |
| Completed | Tranexamic Acid Injection With Different Drainage Clamping Time After Anterior Cruciate Ligament Reconstructio NCT06280456 | Taipei Veterans General Hospital, Taiwan | N/A |
| Recruiting | Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol NCT05968729 | University of Connecticut | N/A |
| Unknown | Physical Activity, Knee Joint Loading and Joint Health NCT05306054 | University of Bath | — |
| Unknown | Comparison of Single-bundle Versus Double-bundle Anterior Cruciate Ligament Reconstruction NCT06303726 | University Medical Centre Maribor | N/A |
| Completed | Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery NCT05136352 | University Hospital, Toulouse | N/A |
| Active Not Recruiting | STABILITY: Physical Activity Intervention at 7 Years Post-Anterior Cruciate Ligament Reconstruction NCT05152758 | Western University, Canada | N/A |
| Completed | Custom Surgical Tray in ACLR Procedure NCT05569889 | University Hospital, Toulouse | — |
| Terminated | Gait-based Evaluation of Early Rehabilitation After ACL Reconstruction NCT05481918 | Karl Landsteiner University of Health Sciences | N/A |
| Withdrawn | Impact of Crutch Type on Gait and Functional Outcomes Post-knee Surgery NCT04258917 | University of Calgary | N/A |
| Completed | The Effect of Aquatic Rehabilitation on Knee Function in Anterior Cruciate Ligament Reconstruction Patients. NCT05929118 | Beijing Sport University | N/A |
| Completed | Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstr NCT04504344 | Arcadia University | Phase 1 |
| Completed | Inter-rater Reliability of the GNRB Arthrometer NCT07200700 | Vastra Gotaland Region | N/A |
| Active Not Recruiting | STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon NCT03935750 | University of Pittsburgh | N/A |
| Unknown | Adding Modified Visual Feedback Training in Patients Following ACL Reconstruction NCT03738436 | China Medical University Hospital | N/A |
| Recruiting | The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injure NCT03552705 | Stanford University | Phase 2 |
| Completed | The Effect of Upper Limbs Motion During Single-leg Jump Landing After Anterior Cruciate Ligament Reconstructio NCT04629092 | National Yang Ming Chiao Tung University | — |
| Unknown | Gait Retraining to Reduce Joint Loading, Inflammation, and PTOA Risk NCT03551678 | VA Palo Alto Health Care System | N/A |
| Terminated | Home Rehabilitation Using Smart Wearable Exercise and Electrical Stimulation Device After Anterior Cruciate Li NCT04079205 | Seoul National University Bundang Hospital | N/A |
| Withdrawn | Iovera° to Treat Pain Associated With ACL Reconstruction and Rehabilitation NCT03688477 | Pacira Pharmaceuticals, Inc | N/A |
| Completed | Effect of PRP Versus BMC in Anterior Cruciate Ligament Reconstruction NCT05191732 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Completed | Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot NCT03481725 | University of California, San Diego | N/A |
| Completed | Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA NCT03631355 | NYU Langone Health | Phase 4 |
| Unknown | Use of Glutamine for Recovery Muscle Strength NCT03517254 | Instituto Nacional de Rehabilitacion | N/A |
| Completed | Predictive Factors for a Successful Return to Run After ACL-R NCT04130308 | Laval University | N/A |
| Unknown | Neurophysiologic Correlates of Movement Planning During Complex Jump Landing Tasks and the Role of Cognitive F NCT03336060 | Goethe University | — |
| Completed | Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reco NCT05248724 | Castilla-La Mancha Health Service | N/A |
| Active Not Recruiting | Fixed Versus Adjustable Loop in ACL Reconstruction NCT03184922 | Royal Devon and Exeter NHS Foundation Trust | N/A |
| Completed | Intraarticular Injection of Tranexamic Acid Reduced Postoperative Hemarthrosis in Arthroscopic Anterior Crucia NCT03580018 | Taipei Veterans General Hospital, Taiwan | N/A |
| Unknown | The Best Method for ACL Reconstruction. NCT03192761 | Lars Konradsen | N/A |
| Completed | Effect of Patient Resilience on Return to Sport Post ACL Reconstruction Surgery NCT03013231 | St. Louis University | — |
| Completed | Chronic Effects of Local Vibration on Neuromuscular Reconditioning After Anterior Cruciate Ligament Reconstruc NCT02929004 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | Rehabilitation Protocol for Reconstruction of Anterior Cruciate Ligament and Anterolateral Knee Ligament Surge NCT03505359 | University of Sao Paulo General Hospital | N/A |
| Completed | Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery NCT02945553 | University of Vermont | Phase 1 / Phase 2 |
| Completed | The Effect of Contralateral Limb Training on Functional Outcomes in Patients With ACL Reconstruction NCT03304561 | Hacettepe University | N/A |
| Active Not Recruiting | Pediatric ACL: Understanding Treatment Options NCT02772770 | Boston Children's Hospital | — |
| Completed | Comparison of 3 Techniques for Recreation of Anterior Cruciate Ligament Anatomic Footprint NCT02795247 | OrthoCarolina Research Institute, Inc. | N/A |
| Completed | Effect of Altered Mechanical Loading in ACLR NCT03035994 | University of North Carolina, Chapel Hill | N/A |
| Withdrawn | interACTION: A Portable Joint Function Monitoring and Training System to Supplement Home Exercise Programs Fol NCT02775188 | University of Pittsburgh | N/A |
| Unknown | Dry Needling Effectiveness of Patients on Break Anterior Cruciate Ligament. NCT02699411 | European University Spain | N/A |
| Completed | Anterior Cruciate Ligament Pain Study NCT02604550 | Emory University | Phase 4 |
| Completed | Multi-scale Modeling for Predictive Characterization of Ligaments and Grafts Behavior in ACL Reconstruction NCT06058494 | Istituto Ortopedico Rizzoli | — |
| Completed | Whole Body Vibration in Individuals Submitted to ACL NCT02609971 | Universidade Federal do Rio Grande do Norte | N/A |
| Completed | AlterG ACL Return to Running Case Series NCT02335645 | Nationwide Children's Hospital | — |
| Terminated | Accelerated vs Non-Accelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Pilot Study NCT03648944 | North Bristol NHS Trust | N/A |
| Completed | Anesthesic Techniques for Surgery of the Anterior Cruciate Ligament of the Knee in Ambulatory Surgery. Randomi NCT02257164 | Centre Hospitalier Universitaire de Saint Etienne | Phase 4 |
| Terminated | Blood Flow Restriction Training in Rehabilitation Patients NCT02174770 | Brooke Army Medical Center | N/A |
| Completed | Early Mobilization of Knee Joint After ACL Surgery. Continuous Passive Motion Versus Manual Passive Mobilizati NCT02748759 | Jesús Montesinos Muñoz | N/A |
| Unknown | Standard ACL Reconstruction vs ACL + Lateral Extra-Articular Tenodesis Study NCT02018354 | University of Western Ontario, Canada | N/A |
| Completed | Study of Pain Management Techniques Following Anterior Cruciate Ligament Repair Surgery NCT01868282 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 / Phase 3 |
| Completed | Comparative Study Between Two Physiotherapy Protocols Conventional X Accelerated in Individuals Undergoing Rec NCT01821599 | University of Sao Paulo | N/A |
| Unknown | Comparison of Two Techniques for Placement of Perineural Femoral Catheters. NCT01726192 | Attikon Hospital | N/A |
| Completed | Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Re NCT01586806 | Hospital for Special Surgery, New York | Phase 4 |
| Completed | Subchondral Microfracture of Tibia After Arthroscopic Anterior Cruciate Ligament Surgery Reconstruction NCT01588977 | Hospital Ambroise Paré Paris | — |
| Unknown | Follow up of Patients Operated With Anterior Cruciate Ligament Reconstruction NCT01279759 | Haraldsplass Deaconess Hospital | — |
| Completed | The Efficacy of Adductor-Canal-Block (ACB) in Patients After Anterior Cruciate Ligament (ACL) Reconstruction NCT01212666 | Glostrup University Hospital, Copenhagen | Phase 4 |
| Terminated | Anterior Cruciate Ligament (ACL) Reconstruction Using Different Grafts and Surgical Techniques NCT00300300 | Queen's University | Phase 4 |
| Completed | SeriACL™ Device (Gen IB) Trial for Anterior Cruciate Ligament (ACL) Repair NCT00775892 | Serica Technologies, Inc. | Phase 1 / Phase 2 |
| Completed | Anterior Cruciate Ligament Reconstruction and Plyometric Exercise NCT01851655 | University of Florida | N/A |
| Completed | Transtibial Versus Anteromedial Femoral Tunnel Technique in ACL Reconstruction NCT02633410 | Panam Clinic | N/A |
| Completed | A Study on Knee Immobilization and Pain Levels After an Anterior Cruciate Ligament (ACL) Reconstruction Surger NCT00338663 | LifeMark Health Research Group | N/A |
| Completed | Effectiveness of Kneehab in Strengthening Quadriceps in Rehabilitation Post Anterior Cruciate Ligament (ACL) R NCT00738010 | Bio-Medical Research, Ltd. | Phase 3 |
| Completed | Effectiveness of Kneehab in Strengthening the Quadriceps of Patients Post Anterior Cruciate Ligament (ACL) Rec NCT00737750 | Bio-Medical Research, Ltd. | Phase 3 |
| Completed | Safety of OMS103HP in Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction NCT00245271 | Omeros Corporation | Phase 3 |
| Withdrawn | Study of RNS60 on Pain and Function After Knee Anterior Cruciate Ligament Surgery NCT01922427 | Revalesio Corporation | Phase 2 |