NCT07537179

Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU

Investigation of the Relationship Between Monocyte Distribution, Monocyte-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio With Acute Phase Reactants in Sepsis in the Intensive Care Unit

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Oguz Gundogdu · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio can be used in addition to conventional biomarkers, and to examine their relationships with these biomarkers.

Detailed description

For Group I (control group) patients, WBC, NLR, MLR, and monocyte distribution(MD) parameters obtained from the complete blood count on the day of their anesthesia outpatient clinic visit were used in the study. For Group II and Group III patients, on the day of sepsis diagnosis, lactate, CRP, PCT, WBC, NLR, MLR, and monocyte distribution(MD) values were recorded. For Groups II and III, SOFA and APACHE-II scores were calculated within the first 24 hours and documented. The day of sepsis diagnosis was defined as T0, and subsequent measurements of lactate, CRP, PCT, WBC, NLR, MLR, and monocyte distribution(MD) were recorded every 48 hours until sepsis resolution, discharge, or death, as T1, T2, T3, and T4, respectively. The monocyte distribution parameter is a research parameter within the complete blood count and does not have a defined reference laboratory range. In our study, statistical analysis of monocyte distribution(MD), MLR and NLR values from the control group was performed to determine a cut-off value.

Conditions

• Sepsis
• Intensive Care (ICU)
• Acute Phase Biomarkers

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Monocyte Distribution	The monocyte distribution parameter is a research parameter within the complete blood count and does not have a defined reference laboratory range.

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-12-30
• Completion: 2024-01-30
• First posted: 2026-04-17
• Last updated: 2026-04-17

Locations

1 site across 1 country: Turkey (Türkiye)