NCT07522918

Single-Session Extraoral PBM After Third Molar Extraction

Single-Session Extraoral Photobiomodulation Reduces Early Postoperative Pain But Not Edema or Trismus After Impacted Mandibular Third Molar Extraction: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Konya Necmettin Erbakan Üniversitesi · Academic / Other
• Sex: All
• Age: 17 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

Postoperative pain, edema, and trismus are frequent complications following impacted mandibular third molar surgery. This randomized controlled trial evaluated the effects of a single-session extraoral dual-wavelength photobiomodulation (PBM) (650+904 nm) applied immediately after extraction. The study aimed to assess the impact of this therapy on postoperative pain, edema, trismus, and quality of life (QoL) on days 2 and 7. The results indicate that PBM effectively reduces early postoperative pain and improves QoL on the second day after surgery, although it does not significantly affect edema or trismus.

Detailed description

This prospective, parallel-group randomized controlled trial was conducted to assess the efficacy of photobiomodulation therapy (PBMT) following the surgical removal of mesioangular impacted mandibular third molars. A total of 70 patients (age range: 17-25 years) were enrolled and randomly allocated to either the PBM group (n=35) or the control group (n=35). The surgical procedure followed a standardized protocol performed by a single surgeon. Following extraction, the PBM group received a single 10-minute session of extraoral PBM using a dual-wavelength (650 nm + 904 nm) GaAlAs laser system. The probe was applied over the mandibular angle-ramus region, delivering a total energy of 270 J. Postoperative evaluations included: Pain and Quality of Life (QoL): Measured using 100-mm Visual Analog Scales (VAS). Edema: Quantified via distances between anatomical reference points. Trismus: Quantified by measuring maximum interincisal distance (MID). Measurements were recorded preoperatively (baseline) and on postoperative days 2 and 7 by a blinded clinical investigator.

Conditions

• Impacted Mandibular Third Molar
• Edema
• Trismus
• Postoperative Pain

Interventions

Type	Name	Description
DEVICE	Dual-wavelength GaAlAs laser (650+904 nm)	Extraoral PBM (GRR Laser) applied for 10 minutes, delivering a total energy of 270 J (fluence: 2.73 J/cm² and irradiance: 4.54 mW/cm²).

Timeline

• Start date: 2025-02-15
• Primary completion: 2026-01-20
• Completion: 2026-01-20
• First posted: 2026-04-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: Turkey (Türkiye)