NCT07521397

Pooled Analysis of Patients With Early-stage Breast Cancer Treated With Adjuvant Dose-dense Sequential Chemotherapy: a Hellenic Cooperative Oncology Group (HeCOG) Study.

Pooled Analysis of Individual Patient Data of Patients With Early-stage Breast Cancer Treated With Adjuvant Dose-dense Sequential Chemotherapy (Ddsc): a Hellenic Cooperative Oncology Group (HeCOG) Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,358 (actual)
• Sponsor: Hellenic Cooperative Oncology Group · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to assess survival outcomes and treatment-related toxicity in patients with early-stage breast cancer receiving adjuvant therapies, using high-quality individual patient data pooled from seven clinical studies conducted by the Hellenic Cooperative Oncology Group (HeCOG), including 3 phase III trials and 4 observational studies. This study aims to assess long-term disease-free survival (DFS) and overall survival (OS), as well as the toxicity patterns associated with dose-dense sequential chemotherapy in intermediate or high-rsk patients.

Conditions

• Breast Cancer
• Early Stage Breast Cancer
• Adjuvant Chemotherapy
• Prognosis Breast Cancer
• Overall Survival

Timeline

• Start date: 1996-12-15
• Primary completion: 2022-07-15
• Completion: 2022-07-15
• First posted: 2026-04-09
• Last updated: 2026-04-09

Locations

1 site across 1 country: Greece