NCT07519226

Effectiveness and Safety of Penehyclidine Hydrochloride for Improving Microcirculatory Dysfunction in Critically Ill Children

Effectiveness and Safety of Penehyclidine Hydrochloride for Improving Microcirculatory Dysfunction in Critically Ill Children: A Single-Center, Prospective, Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 98 (actual)
• Sponsor: Lihua Wen · Academic / Other
• Sex: All
• Age: 28 Days – 18 Years
• Healthy volunteers: Not accepted

Summary

This prospective randomized controlled trial was designed to evaluate whether the M1/M3-selective antagonist penehyclidine hydrochloride could more effectively reverse pediatric microcirculatory dysfunction than traditional atropine, particularly when macrohemodynamics appear normalized.

Conditions

• Shock

Interventions

Type	Name	Description
DRUG	atropine control group	atropine control group
DRUG	penehyclidine hydrochloride group	penehyclidine hydrochloride

Timeline

• Start date: 2024-05-08
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2026-04-09
• Last updated: 2026-04-09

Locations

1 site across 1 country: China