Trials / Not Yet Recruiting

Not Yet RecruitingNCT07519018

TIS for Drug Resistant TLE

Study on the Effect of Temporal Interference Stimulation in the Therapy of Drug Resistant Temporal Lobe Epilepsy

Status: Not Yet Recruiting
Phase: N/A
Study type: Interventional
Enrollment: 30 (estimated)

Sponsor: Xijing Hospital · Academic / Other
Sex: All
Age: 18 Years – 65 Years
Healthy volunteers: Not accepted

Summary

Temporal interference (TI) stimulation is a new neuromodulation method. Compared with traditional neuromodulation therapy, TI has deep targeting and focusing, and it has been confirmed to modulate sleep, cognition, and movement disorders. Recent study shown that TI stimulation targeting the hippocampus could significantly reduce epileptiform discharges, but its efficacy on seizures was still unclear. Therefore, the aim of this study is to observe the therapeutic effect of TI stimulation targeting the hippocampus in patients with refractory temporal lobe epilepsy (TLE) for 5 days, and to provide support for clinical trials of non-invasive treatment of refractory TLE.

Conditions

Epilepsy

Interventions

Type	Name	Description
DEVICE	TI Stimulation	Temporal interference (TI) targeting hippocampus for 5 days.

Timeline

Start date: 2026-04-15
Primary completion: 2027-04-30
Completion: 2028-04-30
First posted: 2026-04-09
Last updated: 2026-04-14

Source: ClinicalTrials.gov record NCT07519018. Inclusion in this directory is not an endorsement.