NCT07513480

Pretreatment With CPA-EE, Metformin and Myoinositol in PCOS With High AMH

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Mst.Sumyara Khatun · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

Women with PCOS with high AMH randomly allocated into group A \& B.Cyproterone acetate plus ethinyl estradiol,metformin \& myoinositol in group A and Cyproterone acetate plus ethinyl estradiol \& metformin are given in group B.Then letrozole 5 mg day 2 to day 6 is given \& ovarian response is seen in day 12 for 3 subsequent 3 months .

Detailed description

Women with PCOS with high AMH randomly allocated into group A \& B.Cyproterone acetate plus ethinyl estradiol once daily ,metformin 500 mg 3 times daily \& myoinositol 750 mg 3 times daily for 3 months in group A and Cyproterone acetate plus ethinyl estradiol once daily ,metformin 500 mg 3 times daily are given in group B. .Then letrozole 5 mg day 2 to day 6 is given \& ovarian response is seen in day 12 for 3 subsequent 3 months .Ovarian response is seen by day 12 folliculometry -mature follice ,developinf follicle and endometrial thickness and day 21 serum progesterone

Conditions

• PCOS

Interventions

Type	Name	Description
DRUG	Cyproterone Acetate, Ethinyl Estradiol Drug Combination	Once daily Cyclically for 3 months
DRUG	Metformin 500 mg	Thrice daily for three months
DIETARY_SUPPLEMENT	Myoinositol 750mg	Thrice daily for three months

Timeline

• Start date: 2024-08-12
• Primary completion: 2025-11-12
• Completion: 2026-02-20
• First posted: 2026-04-07
• Last updated: 2026-04-07

Locations

1 site across 1 country: Bangladesh