NCT07512518

Observational Cohort Study of Chronic Viral Infection in the Central Nervous System

Central Nervous System Chronic Viral Infections: A Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 66 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 14 Years
• Healthy volunteers: Not accepted

Summary

This research team intends to conduct a real-world cohort study of chronic CNS viral infections represented by PML, to evaluate whether administration of immune checkpoint inhibitors improves long-term outcomes in this patient population.Patients with prior follow-up will be enrolled into a retrospective/prospective ambidirectional cohort, and newly diagnosed patients will be enrolled into a prospective cohort.

Conditions

• Progressive Multifocal Leukoencephalopathy
• Immune Checkpoint Inhibitors

Interventions

Type	Name	Description
DRUG	Immune Checkpoint Inhibitors	Immune Checkpoint Inhibitors for PML treatment

Timeline

• Start date: 2023-02-20
• Primary completion: 2030-10-25
• Completion: 2030-10-25
• First posted: 2026-04-06
• Last updated: 2026-04-06

Locations

1 site across 1 country: China