NCT07500844

Decontamination Methods in the Treatment of Peri-implantitis

Treatment of Peri-implantitis by Air-polishing Abrasives and Antiseptics Solutions

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Research Centre for Medical Genetics, Russian Federation · Other Government
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is: Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.

Detailed description

This is a prospective, interventional study involving 48 patients diagnosed with peri-implantitis. Groups: Participants were allocated into three groups (n=16 per group) to receive one of three treatment combinations. Group 1: Treatment with Miramistin solution (0.01%) and air-polishing with sodium bicarbonate powder. Group 2: Treatment with Chlorhexidine solution (0.05%) and air-polishing with erythritol powder. Group 3: Treatment with Octenisept solution and air-polishing with glycine powder. Intervention: Each patient received the assigned combination treatment at intervals of 7-10 days over one month. Outcome Measures: Clinical parameters were assessed at baseline, 1 month, and 2.5 months after the start of treatment: Primary Clinical Outcomes: Changes in probing depth (PD) and bleeding on probing (BOP). Secondary Clinical Outcomes: Changes in plaque index (PLI), gingival index (GI), presence of suppuration, and radiographic bone loss (assessed via periapical radiographs and cone-beam computed tomography (CBCT)). The need for subsequent surgical intervention was also recorded.

Conditions

• Peri-implantitis

Interventions

Type	Name	Description
DRUG	Miramistin	Antiseptic solution (0.01%) used for irrigation of the peri-implant pocket.
PROCEDURE	Sodium Bicarbonate Powder	Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle
DRUG	Chlorhexidine	Antiseptic solution (0.05%) used for irrigation of the peri-implant pocket.
PROCEDURE	Erythritol Powder	Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.
DRUG	Octenisept	Antiseptic solution used for irrigation of the peri-implant pocket.
PROCEDURE	Glycine Powder	Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.

Timeline

• Start date: 2023-02-01
• Primary completion: 2025-11-30
• Completion: 2025-12-11
• First posted: 2026-03-30
• Last updated: 2026-04-03

Locations

1 site across 1 country: Russia