NCT07463391

Chinese Classics Recitation Training in Subjective Cognitive Decline

The Effect of Memory Training by Chinese Classics Recitation on Individuals With Subjective Cognitive Decline

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease. Effective early behavioral interventions remain limited, and the neurobiological mechanisms underlying cognitive training effects are not fully understood, particularly in culturally specific educational contexts. This randomized, assessor-blinded, controlled clinical trial will enroll 60 individuals with SCD to evaluate the effects of a six-month structured Chinese Classics recitation training program. Participants will be randomly assigned to either an intervention group or a non-active control group. Assessments will be conducted at baseline, immediately post-intervention, and during annual follow-up. Multimodal evaluations will include neuropsychological testing, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), blood biomarker profiling, gut microbiota analysis, and fecal metabolomics. The study aims to examine clinical outcomes and explore potential neurobiological and systemic correlates associated with culturally adapted cognitive training.

Conditions

• Subjective Cognitive Decline (SCD)
• Subjective Cognitive Decline

Interventions

Type	Name	Description
BEHAVIORAL	Memory training by Chinese Classics recitation	At least five minutes memory training per day, for six months

Timeline

• Start date: 2026-08-01
• Primary completion: 2029-07-31
• Completion: 2032-12-31
• First posted: 2026-03-11
• Last updated: 2026-03-11

Locations

1 site across 1 country: Taiwan