NCT07456605

Study of the Safety and Usefulness of Liposomal Curcumin in Multiple Myeloma

Phase I Study of Safety and Efficacy of Liposomal Curcumin in Relapsed Refractory Multiple Myeloma

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to test the safety of in investigational drug called Liposomal curcumin (LipoCurc) and to find the highest dose that can be given without causing very severe side effects. To do this participants are given LipoCurc and are watched very closely to see what side effects they have and to make sure the side effects are not severe. If the side effects are not severe, then new participants will be given a higher dose of LipoCurc. Participants joining this study later on will get higher doses of LipoCurc than participants who join earlier. This will continue until a dose is found that causes severe but temporary side effects. Doses higher than that will not be given.

Detailed description

LipoCurc contains a substance called curcumin. Curcumin is a natural ingredient found in a plant called turmeric, which is a herb used in traditional Indian and Chinese medicine. Curcumin has been shown in the laboratory to have antioxidant (may help prevent damage to cells),anti-inflammatory (may help reduce swelling, redness, or pain), and anti-cancer (can kill multiple myeloma cells) properties. Curcumin supplements you can buy at a drugstore as pills are not absorbed well by the body. This product has been developed so your body can absorb much more of it through an infusion into the veins.

Conditions

• Multiple Myeloma Refractory
• Multiple Myeloma in Relapse

Interventions

Type	Name	Description
DRUG	Liposomal Curcumin (LipoCurc)	LipoCurc contains a substance called curcumin. Curcumin is a natural ingredient found in a plant called turmeric, which is a herb used in traditional Indian and Chinese medicine. Curcumin has been shown in the laboratory to have antioxidant (may help prevent damage to cells),anti-inflammatory (may help reduce swelling, redness, or pain), and anti-cancer (can kill multiple myeloma cells) properties. Curcumin supplements you can buy at a drugstore as pills are not absorbed well by the body. This product has been developed so your body can absorb much more of it through an infusion into the veins.

Timeline

• Start date: 2026-03-02
• Primary completion: 2028-03-02
• Completion: 2028-03-02
• First posted: 2026-03-06
• Last updated: 2026-03-06

Locations

1 site across 1 country: Canada