NCT07450716

Assessing the Efficacy and Safety of Photobiomodulation for the Treatment of Pruritus

• Status: Not Yet Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to evaluate the safety and effectiveness of a low-level near-infrared LED light device for relieving itch. The device is non-invasive, does not break the skin, and does not produce heat. Near-infrared light has been used in other medical settings and is known to interact with skin and nerve pathways. In this study, researchers are examining whether this light can be safely applied to the skin and whether it may help reduce itch by affecting signals involved in itch sensation.

Conditions

• Pruritus

Interventions

Type	Name	Description
DEVICE	Light-emitting diode (LED) Photobiomodulation (PBM) device	Near-infrared light treatment will be administered to an area on the body experiencing itch.
OTHER	Placebo	Matching placebo delivered by placing the device above the skin on an area contralateral to the treatment area without activating it.

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2026-03-05
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study