NCT07450235

Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls

Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Université de Nantes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals. Researchers will measure inflammation-related biomarkers in saliva, gingival fluid, and dental pulp samples to determine whether these substances reflect the level of inflammation. The study also evaluates whether saliva and oral fluids could be used as simple, non-invasive tools to detect and monitor pulp inflammation. We hypothesize that patients with pulpitis will show different biomarker levels compared with healthy controls.

Conditions

• Pulpitis
• Healthy

Timeline

• Start date: 2026-03-01
• Primary completion: 2028-07-01
• Completion: 2028-12-01
• First posted: 2026-03-04
• Last updated: 2026-03-04

Locations

1 site across 1 country: France