NCT07442578

Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial

Impact Of Exercise Intensity On Cardiac Health In Young Adult Survivors Of Childhood Cancer: The PULSE Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Dana-Farber Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years – 39 Years
• Healthy volunteers: Not accepted

Summary

This trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines.

Detailed description

This phase 1, pilot, randomized clinical trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines. Participants will be randomized into 1 of 2 study groups: Arm 1: High-intensity interval training (HIIT) or Arm 2: moderate intensity continuous training (MICT). The research study procedures include screening for eligibility, in-clinic visits, questionnaires, measurements of height, weight, waist, and hip circumference, blood pressure, cardiopulmonary fitness, activity measurements, blood tests, and electrocardiograms (ECGs). Participation in this research study is expected to last about 4 months. It is expected that about 20 people will take part in this research study.

Conditions

• Childhood Cancer Survivors
• Cardiotoxicity
• Cardiovascular Diseases
• Anthracycline-induced Cardiotoxicity

Interventions

Type	Name	Description
BEHAVIORAL	HIIT Exercise Program	Exercise program with stationary bike via the Zoom platform.
BEHAVIORAL	MICT Exercise Program	Exercise program with stationary bike via the Zoom platform.

Timeline

• Start date: 2026-03-04
• Primary completion: 2027-03-04
• Completion: 2028-03-04
• First posted: 2026-03-02
• Last updated: 2026-03-18

Locations

1 site across 1 country: United States