NCT07426744

Antipyretic Therapy With and Without Cold Sponging

Antipyretic Therapy With and Without Cold Sponging: A Comparative Study in Febrile Children.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (estimated)
• Sponsor: Muhammad Aamir Latif · Academic / Other
• Sex: All
• Age: 6 Months – 60 Months
• Healthy volunteers: Not accepted

Summary

This study aims to fill the gaps regarding the effectiveness of paracetamol alone with paracetamol combined with cold sponging in febrile children.

Detailed description

Given the conflicting findings in existing literature, the role of cold sponging in fever management remains uncertain. Some studies suggest a transient advantage in early temperature reduction, while others highlight limited long-term benefit and increased discomfort. Therefore, this study seeks to determine whether cold sponging offers meaningful additional benefit or merely adds distress without enhancing the efficacy of paracetamol. The findings would generate evidence-based guidance for using cold sponging in febrile children.

Conditions

• Fever

Interventions

Type	Name	Description
DRUG	Paracetamol	Children will receive paracetamol alone, as a single dose of paracetamol syrup (15 mg/kg) orally.
COMBINATION_PRODUCT	Paracetamol+Cold Sponging	Children will receive paracetamol as a single dose of paracetamol syrup (15 mg/kg) orally, and cold sponging will be performed immediately following paracetamol administration for 15 minutes, using room-temperature water (approximately 25°C) to sponge the forehead, arms, and legs.

Timeline

• Start date: 2026-03-01
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2026-02-23
• Last updated: 2026-02-23

Locations

1 site across 1 country: Pakistan