NCT07414355

Switching to E-Cigarettes After Type 2 Diabetes Diagnosis and Health Outcomes

Clinical Outcomes Associated With Switching From Combustible Cigarettes to Electronic Cigarettes Among Adults With Newly Diagnosed Type 2 Diabetes: A Nationwide Retrospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 133,320 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Individuals with T2DM who smoke have higher risks of cardiovascular disease and other complications. Many people consider e-cigarette as a "harm-reduction" alternatives to combustible cigarettes, but it is not clear whether switching to e-cigarettes improves health outcomes in patients with diabetes.

Detailed description

Use of electronic cigarettes has increased, partly driven by the perception that they may serve as a "harm-reduction" alternative to combustible cigarettes. Evidence cited in prior work includes higher cessation rates versus nicotine replacement therapy in a randomized trial and reductions in biomarkers of potential harm after switching from combustible cigarettes to e-cigarettes; observational data in high-risk PCI populations have also suggested lower MACCE risk after switching. However, constituents such as nicotine and heavy metals may adversely affect diabetes management, and most prior studies have emphasized potential harms of e-cigarette use itself. As a result, whether switching from combustible cigarettes to e-cigarettes confers a harm-reduction benefit in patients with diabetes remains uncertain. In this regards, the current study evaluated clinical outcomes associated with switching from combustible cigarettes to e-cigarettes in patients with diabetes and to assess whether the degree of switching (partial vs full transition) modifies the risk of adverse clinical events.

Conditions

• Diabete Type 2
• E Cigarette Use
• Clinical Outcomes

Interventions

Type	Name	Description
BEHAVIORAL	Switching to E-cigarette	Switching to E-cigarette

Timeline

• Start date: 2018-01-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2026-02-17
• Last updated: 2026-02-17

Locations

1 site across 1 country: South Korea