NCT07409350

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 398 (estimated)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study includes finalization of the LINKED social network intervention to improve PrEP and MOUD uptake among people who inject drugs (PWID) in collaboration with an Expert Advisory Board and staff (N=16) at The Sidewalk Project (TSP), followed by a Hybrid Type II cluster randomized trial of the LINKED intervention (versus an equal-attention control) among N=372 people who inject drugs, with 6- and 12-month follow-up assessment of PrEP and MOUD uptake. The investigators will also evaluate implementation outcomes to inform future sustainable implementation of LINKED in harm reduction organizations.

Conditions

• Substance Use
• HIV Prevention

Interventions

Type	Name	Description
BEHAVIORAL	LINKED	LINKED is a theory-driven social network intervention (SNI) that leverages peer influence within the social networks of people who inject drugs (PWID) to disseminate information, encourage communication, and increase pre-exposure prophylaxis (PrEP) and medications for opioid use disorder (MOUD) uptake and persistence in harm reduction organization (HRO) settings.
BEHAVIORAL	Group Intervention	Group intervention facilitated by trained study staff that supports critical thinking about what constitutes low, medium, and high risks for HIV and overdose.

Timeline

• Start date: 2027-01-01
• Primary completion: 2028-12-01
• Completion: 2028-12-01
• First posted: 2026-02-13
• Last updated: 2026-02-13

Locations

3 sites across 1 country: United States