NCT07405060

Impacts and Mechanisms of Age and Muscle Fatigue on Postural Control and Force Control

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 140 (estimated)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Muscle fatigue is one of the clinical symptoms in elderly people and demonstrates task dependency and muscle dependency. Muscle fatigue has been shown to negatively impact postural control, physical activity, and quality of life. However, the evidence for the influence of muscle fatigue on postural control is limited and inconsistent in elderly people. Therefore, this study aims to investigate the impacts of aging and muscle fatigue on postural control and gait performance with fatiguing exercises of upper and lower extremities.

Detailed description

This study aims to investigate the effects of muscle fatigue on postural control and gait performance in healthy older adults (≥65 years) and young adults (20-40 years). Neuromuscular fatigue has been associated with postural instability, but its influence on gait and potential age-related differences remain unclear. Therefore, this study will compare fatigue-induced changes in motor performance between age groups and examine whether fatigue of the upper and lower extremities produces similar functional effects. Healthy older adults and young adults will be recruited from the community. Eligible participants must be in good health, able to walk independently, demonstrate normal cognitive function, and provide informed consent. Individuals with neurological, cardiovascular, musculoskeletal, or other conditions that may affect motor performance will be excluded. A repeated-measures design will be used. The study will involve two laboratory sessions separated by at least one week. Participants will undergo pre-test assessments, a fatiguing exercise protocol, and post-test assessments. Motor outcomes-including maximal voluntary isometric contraction, postural control, and gait performance-will be measured before and after the fatiguing exercises. Fatiguing exercises will consist of repeated cycles of maximal contractions with rest periods, while heart rate and perceived exertion are monitored to ensure safety. The protocol will terminate if exertion reaches a predefined threshold or heart rate exceeds the age-predicted maximum. Surface electromyography and electrical stimulation will be used to assess neuromuscular function. Postural control will be evaluated using a force plate under multiple standing conditions, and gait parameters will be measured while participants walk at comfortable and fast speeds. Statistical analyses will use repeated-measures mixed-model ANOVAs to examine the effects of age group and fatigue on motor outcomes.

Conditions

• Aging
• Muscle Fatigue

Interventions

Type	Name	Description
OTHER	Age	We compare the young and the old groups
OTHER	Muscle fatigue	We compare the results before and after muscle fatigue

Timeline

• Start date: 2022-08-01
• Primary completion: 2028-07-31
• Completion: 2028-07-31
• First posted: 2026-02-12
• Last updated: 2026-02-12

Locations

2 sites across 1 country: Taiwan