NCT07398820

IMPACT OF SEDENTARY BEHAVIOR IN THE HOMEOSTASIS OF THE DIGESTIVE ECOSYSTEM

Association of Sedentary Behavior and Physical Activity With Gut Transit Time and Its Effect on Gut Microbiota Inflammatory and Carcinogenic Potential

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Clínica Universidad de los Andes · Academic / Other
• Sex: All
• Age: 40 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study seeks to determine the relationship between sedentary behavior, gut transit, gut microbiota and polyps development. Will be conducted an evaluation which includes assessments of physical activity behaviors (through accelerometry), gut transit time (ingestion of two blue colored muffins), food ingestion (online nutritional survey), body composition (through bioimpedance), heart rate variability (with a heart rate monitor) and gut microbiota composition (from a fecal sample). The main goal of this study is to see if there is a relationship between high sedentary time and a slower gut transit time, altering gut microbiota favoring dysbiosis and promoting polyps development. For this objective, it will be described gut microbiota composition (identifying which bacteria are present in the gut and in what quantities are they found), physical activity and sedentary behaviors time, gut transit time (how long does it take to defecate after eating a meal) in order to relate these factors with the presence of polyps.

Conditions

• Healthy
• Colorectal Adenoma

Interventions

Type	Name	Description
OTHER	Initial assessment	Patients will be cited to the clinic for an initial assessment that will include: * Brief interview to identify health conditions and medicines * Fecal sample recollection for determination of gut microbiota composition * Physical activity assessment with 7-day accelerometry * Body composition through octopolar bioimpedance * Heart rate variability with a heart rate monitor * Food ingestion through a questionnaire

Timeline

• Start date: 2023-05-01
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2026-02-10
• Last updated: 2026-02-10

Locations

1 site across 1 country: Chile