NCT07394738

Using Different Biomaterials to Preserve Bone After Tooth Extraction

Evaluating the Effectiveness of Various Biomaterials for Alveolar Socket Preservation

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Inonu University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This clinical study aims to evaluate the effectiveness of different biomaterials in alveolar socket preservation following tooth extraction. Participants will be allocated into three groups: (1) dentin graft, (2) dentin graft combined with hyaluronic acid, (3) allograft and (4) natural healing without any grafting material (control group). At 4 months post-extraction, dental implants will be placed, and bone biopsies will be obtained during the procedure. These biopsy samples will be subjected to histological analysis to assess new bone formation and graft integration. The study will contribute to the understanding of biomaterial performance in socket preservation prior to implant placement.

Detailed description

This randomized clinical trial is designed to evaluate the clinical and histological outcomes of different biomaterials used for alveolar socket preservation following tooth extraction. A total of 40 systemically healthy adult patients requiring tooth extraction in the non-molar region will be enrolled and randomly assigned to one of the following three groups (10 patients per group): Group 1: Extraction socket filled with autogenous dentin graft. Group 2: Extraction socket filled with autogenous dentin graft combined with hyaluronic acid. Group 3: Extraction socket filled with allograft. Group 4 (Control): Extraction socket left to heal naturally without any graft material. All patients will be re-evaluated at 4 months post-extraction, at which time dental implant placement will be performed. During the implant surgery, bone core biopsies will be taken from the grafted sites using a trephine bur for histological analysis. These specimens will be evaluated to assess new bone formation, residual graft material, inflammatory response, and overall bone quality. Clinical parameters such as soft tissue healing, postoperative complications, and patient-reported outcomes will also be recorded throughout the healing period. This study aims to compare the regenerative potential of dentin graft, allograft and dentin graft combined with hyaluronic acid, and to determine whether these materials can enhance socket healing and improve bone quality prior to implant placement.

Conditions

• Alveolar Ridge Preservation
• Bone Regeneration
• Tooth Extraction
• Dental Implants

Interventions

Type	Name	Description
OTHER	Allograft	Following tooth extraction, the socket is filled with particulate freeze-dried allograft. The material is placed in a single session immediately after extraction to support socket preservation. Healing is monitored clinically at scheduled follow-up visits.
OTHER	Autogenous Dentin Graft	After tooth extraction, autogenous dentin is processed into particulate graft form and placed into the socket in the same session. The graft is used for socket preservation, and healing is assessed clinically during planned follow-up visits.
OTHER	Hyaluronic Acid Gel	A hyaluronic acid gel is applied as an adjunct biomaterial in combination with dentin graft material during socket preservation. Tissue response is evaluated at scheduled follow-up visits.

Timeline

• Start date: 2025-04-09
• Primary completion: 2026-04-30
• Completion: 2026-06-01
• First posted: 2026-02-06
• Last updated: 2026-03-27

Locations

1 site across 1 country: Turkey (Türkiye)