NCT07393217

Correlation Between Circulating Fibroblast Activation Protein (FAP) and Fibrosis in Two Diseases (Rheumatoid Arthritis and Systemic Sclerosis)

Circulating Fibroblast Activation Protein (FAP) As A Marker for Fibroblast-Driven Pathology in Rheumatoid Arthritis and Systemic Sclerosis : Implication for Joint, Skin and Lung Fibrosis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 111 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation. A small blood sample will be taken from participants (RA , SSc patients and healthy people ), and the FAP level will be measured and compared with routine clinical examinations, imaging studies, and lung function tests. The purpose of this study is to improve understanding of disease activity and lung involvement in these conditions and to explore whether FAP could be useful as a blood marker for future patients. Participation in this study will not change the participant's usual medical care.

Conditions

• Rheumatoid Arthritis (RA)
• Systemic Sclerosis (SSc)

Timeline

• Start date: 2026-03-01
• Primary completion: 2027-03-01
• Completion: 2027-09-01
• First posted: 2026-02-06
• Last updated: 2026-02-06

Locations

1 site across 1 country: Egypt