NCT07379463

Amino Acid Transporter System PET/CT Imaging in AATS-Related Diseases

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Tianjin Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

To evaluate the potential usefulness of 11C/18F-MET/FET positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various amino acid transporter system (AATS)-related disease patients.

Detailed description

Subjects with various AATS-related disease (Primary Hyperparathyroidism, Glioma, et al) patients underwent 11C/18F-MET/FET PET/CT either for an initial assessment or for recurrence detection. Lesions uptake was quantified by the maximum standard uptake value (SUVmax). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 11C/18F-MET/FET were calculated.

Conditions

• Amino-Acid Transport Disorder
• Primary Hyperparathyroidism
• Glioma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	11C/18F-MET/FET	Each subject receive a single intravenous injection of 11C/18F-MET/FET, and undergo PET/CT imaging within the specificed time

Timeline

• Start date: 2013-08-29
• Primary completion: 2033-08-29
• Completion: 2033-08-29
• First posted: 2026-01-30
• Last updated: 2026-01-30

Locations

2 sites across 1 country: China