NCT07374198

Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression

Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression: A Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 142 (estimated)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression

Conditions

• Depression
• Anxiety
• S-ketamine
• Breast Cancer

Interventions

Type	Name	Description
DRUG	Esketamine 0.3mg/kg	A single intravenous bolus of 0.3 mg/kg of esketamine is administered during anesthesia induction, and the infusion is completed over 40 minutes.
DRUG	normal saline	Receiving the same volume of normal saline during induction of anesthesia.

Timeline

• Start date: 2026-01-18
• Primary completion: 2026-01-18
• Completion: 2027-02-01
• First posted: 2026-01-28
• Last updated: 2026-01-28