NCT07350369

Research on Early Warning and Diagnosis & Treatment Pathway for Micro Kidney Stones

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Exploring abnormal metabolism in kidney stone patients and developing drugs for kidney stone treatment and their mechanisms of action.

Detailed description

For eligible subjects who meet the inclusion and exclusion criteria, one tube (approximately 4 mL each) of blood and urine samples collected prior to surgery during hospitalization and already tested in clinical laboratories will be gathered. Serum will be separated from the blood samples, while the entire urine sample will be submitted without processing, for further targeted metabolomics analysis. By analyzing the results of targeted metabolomic profiling of amine-related substances, differences in amines and metabolites in blood and urine between kidney stone patients and healthy individuals will be assessed. By measuring and comparing the levels of amine compounds in blood and their corresponding metabolites in urine, statistical analysis will be performed to identify specific amines that are elevated in blood and whose metabolites are simultaneously increased in urine. The underlying mechanisms of these elevations will be further investigated through experimental studies.

Conditions

• Kidney Stone

Interventions

Type	Name	Description
OTHER	Detect the levels of metabolites in blood and urine	Detect the levels of metabolites in blood and urine

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-01-01
• Completion: 2026-03-09
• First posted: 2026-01-20
• Last updated: 2026-03-12

Locations

1 site across 1 country: China