NCT07344844

Adaptive Stereotactic Radiotherapy for Localized Prostate Cancer

Intérêt de la radiothérapie Adaptative en stéréotaxie Prostatique

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Clinique Sainte Clotilde · Academic / Other
• Sex: Male
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates whether adaptive stereotactic body radiotherapy (SBRT) provides dosimetric advantages compared to non-adaptive SBRT in localized prostate cancer. Five low-dose CT scans are performed before each SBRT session to assess anatomical variations (bladder filling, rectal volume) and determine if a dosimetric recalculation would have been required. The study also evaluates cumulative dose to organs at risk, patient-reported quality of life over 24 months, and overall and recurrence-free survival.

Conditions

• Prostate Cancer (Adenocarcinoma)

Interventions

Type	Name	Description
OTHER	Low-dose CT imaging before each SBRT session	Five low-dose, non-contrast CT scans performed immediately before each SBRT session (≈10 min before treatment) to assess anatomical variations impacting target volume and organ-at-risk dosimetry.

Timeline

• Start date: 2025-11-18
• Primary completion: 2029-03-01
• Completion: 2029-05-01
• First posted: 2026-01-15
• Last updated: 2026-01-15

Locations

1 site across 1 country: Reunion