NCT07337772

Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty

Prospective Randomized Controlled Trial Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: First Affiliated Hospital of Fujian Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.

Conditions

• Adrenal Cortex Hormones
• Arthroplasty, Replacement, Knee
• Anesthesia, Local

Interventions

Type	Name	Description
DRUG	LIA with different doses of Diprospan	LIA with different doses of Diprospan

Timeline

• Start date: 2026-02-01
• Primary completion: 2028-11-01
• Completion: 2028-11-01
• First posted: 2026-01-13
• Last updated: 2026-01-13

Locations

1 site across 1 country: China